[P75神经营养因子受体的研究进展与骨不连治疗新思路]
[Research progress of P75 neurotrophin receptor and new idea of nonunion treatment].
作者信息
Li Jiayong, Wang Ming, Peng Chengfei, Bei Chaoyong
机构信息
Department of Limb Trauma, Affiliated Hospital of Guilin Medical College, Guilin Guangxi, 541001, P.R.China.
Department of Limb Trauma, Affiliated Hospital of Guilin Medical College, Guilin Guangxi, 541001,
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2017 Jan 15;31(1):105-109. doi: 10.7507/1002-1892.201609008.
OBJECTIVE
To review the research progress of P75 neurotrophin receptor (P75NTR) so as to clarify its mechanism, and to explore its relationship with nonunion so as to provide a new idea for the treatment of nonunion.
METHODS
The related domestic and foreign literature of P75NTR in recent years was extensively reviewed, summarized, and analyzed to find out the mechanism of action of P75NTR and the pathological factors of nonunion formation.
RESULTS
P75NTR can express in nonunion tissues and lead to defect of fibrin degradation and inhibition of angiogenesis, which play an important role in the pathogenesis of nonunion.
CONCLUSION
It needs to be confirmed by further study whether the purpose of treating nonunion can be achieved by blocking the effects described above of P75NTR.
目的
回顾P75神经营养因子受体（P75NTR）的研究进展，以阐明其作用机制，并探讨其与骨不连的关系，为骨不连的治疗提供新思路。
方法
广泛查阅、总结和分析近年来国内外有关P75NTR的相关文献，以找出P75NTR的作用机制及骨不连形成的病理因素。
结果
P75NTR可在骨不连组织中表达，导致纤维蛋白降解缺陷和血管生成抑制，这在骨不连的发病机制中起重要作用。
结论
通过阻断P75NTR上述作用是否能达到治疗骨不连的目的，有待进一步研究证实。
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