高度 N-甲基化肽 Jahanyne 的全合成。
Total Synthesis of the Highly N-Methylated Peptide Jahanyne.
机构信息
The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Tianjin Key Laboratory of Molecular Drug Research, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) , Nankai University , Tianjin 300350 , People's Republic of China.
出版信息
J Org Chem. 2018 Jun 15;83(12):6741-6747. doi: 10.1021/acs.joc.8b00503. Epub 2018 Jun 7.
PMID:29798667
Abstract
Total synthesis of jahanyne (1) was achieved from commercially available materials on a 38 mg scale. The Boc- N-Me- L-Val-OH fragment along with the HATU/DIPEA coupling condition was applied to avoid the diketopiperazine side reaction in solution phase synthesis.
摘要
从商业可得的材料出发，以 38 毫克规模实现了 jahanyne（1）的全合成。Boc-N-Me-L-Val-OH 片段与 HATU/DIPEA 偶联条件一起被应用，以避免在溶液相合成中双酮哌嗪的副反应。
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