The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, China.
Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300350, China.
Mar Drugs. 2018 Sep 17;16(9):338. doi: 10.3390/md16090338.
The first total synthesis of carmabin A and dragomabin was achieved at 52.3 mg and 43.8 mg scale, respectively. The synthesis led to determination of the configuration of carmabin A and reassignment of the configuration of dragomabin at the stereogenic centre on the alkyne-bearing fragment.
卡马宾 A 和龙舌兰素 A 的全合成首次在 52.3 毫克和 43.8 毫克规模上实现，分别。该合成确定了卡马宾 A 的构型，并重新确定了带有炔烃片段的手性中心处龙舌兰素 A 的构型。
