Novikova L B, Minibaeva G M
Bashkir State Medical University, Ufa, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(3. Vyp. 2):43-47. doi: 10.17116/jnevro20181183243-47.
Ischemic stroke (IS) is one of the leading causes of death and disability worldwide. Among all the causes of IS, cardioembolic stroke (CEI) accounts for up to 40%. Based on the literature data, modern ideas about the role and location of cardiac diseases in the pathogenesis of CEI are presented. The leading cause of CEE is non-rheumatic atrial fibrillation. Numerous attempts to study and prove the genetic nature of the development of IS led to the discovery of new markers - micribonucleic acids (microRNAs), the regulators of gene expression, that inhibit mRNA translation and play a key role in the pathogenesis of IS. This review summarizes the current knowledge of microRNAs, their ability to simultaneously regulate several target genes, and their significance as potential diagnostic and prognostic biomarkers in IS.
缺血性中风（IS）是全球范围内导致死亡和残疾的主要原因之一。在所有导致IS的原因中，心源性栓塞性中风（CEI）占比高达40%。基于文献数据，本文介绍了关于心脏病在CEI发病机制中的作用和位置的现代观点。CEE的主要原因是非风湿性心房颤动。众多研究和证明IS发生的遗传本质的尝试导致了新标志物——微小核糖核酸（microRNAs）的发现，微小核糖核酸是基因表达的调节因子，可抑制mRNA翻译并在IS发病机制中起关键作用。本综述总结了目前关于微小核糖核酸的知识、它们同时调节多个靶基因的能力以及它们作为IS潜在诊断和预后生物标志物的意义。
