Aitbaev K A, Murkamilov I T, Fomin V V, Murkamilova J A, Yusupov F A
Scientific and Research Institute of Molecular biology and medicine, Bishkek, Kyrgyzstan.
Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan; Kyrgyz Russian Slavic University named after the First President of Russia B.N. Yeltsin, Bishkek, Kyrgyzstan.
Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(3. Vyp. 2):48-56. doi: 10.17116/jnevro20181183248-56.
Today, stroke is the third most common pathology after cardiovascular disease and cancer, as well as the leading cause of disability in the world. Although some progress has been made in the field of primary and secondary stroke prevention over the past few decades, a deeper knowledge of the pathophysiology of the disease is needed to significantly improve diagnosis and therapy. MicroRNA (miRNA) is an important, recently identified class of posttranscriptional regulators of gene expression. MiRNA can be used as a tool for therapeutic interventions. This review considers a role of miRNAs in the regulation of experimental stroke and in the development of carotid artery stroke. A potential role of miRNAs as promising biomarkers of stroke is discussed.
如今，中风是仅次于心血管疾病和癌症的第三大常见病症，也是全球致残的主要原因。尽管在过去几十年里，原发性和继发性中风预防领域已取得一些进展，但仍需要更深入了解该疾病的病理生理学，以显著改善诊断和治疗。微小RNA（miRNA）是一类重要的、最近才被发现的基因表达转录后调节因子。MiRNA可作为治疗干预的工具。本文综述了miRNA在实验性中风调节及颈动脉中风发展过程中的作用。还讨论了miRNA作为中风潜在生物标志物的可能性。
