Gusev E I, Martynov M Yu, Kostenko E V, Petrova L V, Bobyreva S N
Pirogov Russian National Research Medical University, Ministry of Health of Russiа, Moscow, Russia.
Pirogov Russian National Research Medical University, Ministry of Health of Russiа, Moscow, Russia; Moscow Centre for Research and Practice in Medical Rehabilitation, Restorative and Sports Medicine, Moscow Healthcare Department, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(3. Vyp. 2):61-68. doi: 10.17116/jnevro20181183261-68.
To evaluate the efficacy of semax and timing of rehabilitation on the dynamics of plasma BDNF levels, motor performance, and Barthel index score in patients after ischemic stroke (IS).
One hundred and ten patients after IS (43 men, 67 women, mean age 58.0±9.7, Ме 63 years) were examined. All patients were divided into early (89±9 days) and late (214±22 days) rehabilitation groups. Each group was subdivided into semax+ and semax- subgroups. Standard regimen of semax included 2 courses (6000 mcg/day) for 10 days with 20 day interval. Plasma BDNF levels, motor performance on the British Medical Research Council scale and Barthel index were assessed in all groups.
Administration of semax, regardless of the timing of rehabilitation, increased BDNF plasma levels which remained high during the whole study period. In semax- subgroups high BDNF plasma levels were positively correlated with early rehabilitation. Administration of semax and high BDNF levels accelerated the improvement and ameliorated the final outcome of Barthel score index. There was a positive correlation between BDNF plasma levels and Barthel score, as well as a correlation between early rehabilitation and motor performance improvement. The correlation between BDNF plasma levels and Barthel score was modified by the timing of rehabilitation.
Early rehabilitation and administration of semax increase BDNF plasma level, speed functional recovery, and improve motor performance.
评估赛美克斯（semax）的疗效以及康复时机对缺血性脑卒中（IS）患者血浆脑源性神经营养因子（BDNF）水平动态变化、运动功能及巴氏指数评分的影响。
对110例IS患者（43例男性，67例女性，平均年龄58.0±9.7岁，中位数63岁）进行检查。所有患者分为早期（89±9天）和晚期（214±22天）康复组。每组再分为赛美克斯+和赛美克斯-亚组。赛美克斯的标准治疗方案为2个疗程（6000微克/天），持续10天，间隔20天。评估所有组的血浆BDNF水平、英国医学研究委员会量表的运动功能及巴氏指数。
无论康复时机如何，赛美克斯的使用均提高了血浆BDNF水平，且在整个研究期间一直保持较高水平。在赛美克斯-亚组中，较高的血浆BDNF水平与早期康复呈正相关。赛美克斯的使用及较高的BDNF水平加速了改善过程并改善了巴氏评分指数的最终结果。血浆BDNF水平与巴氏评分之间存在正相关，早期康复与运动功能改善之间也存在相关性。血浆BDNF水平与巴氏评分之间的相关性因康复时机而改变。
早期康复及赛美克斯的使用可提高血浆BDNF水平，加快功能恢复并改善运动功能。
