Department Earth and Planetary Sciences and Origin of Life Initiative, Harvard University, 20 Oxford Street, Cambridge, 02138, Massachusetts, USA.
Santa Fe Institute, Santa Fe, New Mexico, 87501, USA.
Chemistry. 2018 Jul 25;24(42):10621-10624. doi: 10.1002/chem.201801633. Epub 2018 Jun 28.
The direct synthesis of block copolymer vesicles on the scale of tens to hundreds of nanometers using reversible addition-fragmentation chain transfer (RAFT) dispersion polymerization as an effect of chemical oscillations is reported. RAFT polymerization is successfully accomplished between polyethylene glycol containing a RAFT agent (PEG-CTA) and ethyl acrylate monomer in the presence of the Belousov-Zhabotinsky (B-Z) reaction in oscillatory mode. The self-assembly of poly(ethylene glycol)-b-poly(ethyl acrylate) unimers gives rise to spherical micelles. The self-assembled micelles reorganize and transform to vesicles. All the chemistry of polymerization, self-assembly and self-organization, of macromolecules takes place in a single pot using only a few simple raw materials in aqueous solution.
本文报道了使用可逆加成-断裂链转移（RAFT）分散聚合在数十到数百纳米范围内直接合成嵌段共聚物囊泡的方法，这种聚合是化学振荡的结果。在存在 Belousov-Zhabotinsky（B-Z）反应的情况下，成功地在含有 RAFT 试剂（PEG-CTA）的聚乙二醇和丙烯酸乙酯单体之间进行 RAFT 聚合。聚（乙二醇）-b-聚（丙烯酸乙酯）单体的自组装形成了球形胶束。自组装的胶束重新排列并转化为囊泡。使用仅在水溶液中使用几种简单原料，在单个容器中即可完成聚合、自组装和大分子自组织的所有化学反应。
