Institute of Developmental Genetics, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), 85764 Neuherberg, Germany.
Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.
Genes Dev. 2018 May 1;32(9-10):602-619. doi: 10.1101/gad.314674.118.
Lipid peroxidation is the process by which oxygen combines with lipids to generate lipid hydroperoxides via intermediate formation of peroxyl radicals. Vitamin E and coenzyme Q react with peroxyl radicals to yield peroxides, and then these oxidized lipid species can be detoxified by glutathione and glutathione peroxidase 4 (GPX4) and other components of the cellular antioxidant defense network. Ferroptosis is a form of regulated nonapoptotic cell death involving overwhelming iron-dependent lipid peroxidation. Here, we review the functions and regulation of lipid peroxidation, ferroptosis, and the antioxidant network in diverse species, including humans, other mammals and vertebrates, plants, invertebrates, yeast, bacteria, and archaea. We also discuss the potential evolutionary roles of lipid peroxidation and ferroptosis.
脂质过氧化是指氧与脂质结合，通过中间形成过氧自由基生成脂质氢过氧化物的过程。维生素 E 和辅酶 Q 与过氧自由基反应生成过氧化物，然后这些氧化的脂质可以被谷胱甘肽和谷胱甘肽过氧化物酶 4 (GPX4) 和细胞抗氧化防御网络的其他成分解毒。铁死亡是一种涉及铁依赖性脂质过氧化的调节性非凋亡细胞死亡形式。在这里，我们综述了不同物种（包括人类、其他哺乳动物和脊椎动物、植物、无脊椎动物、酵母、细菌和古菌）中脂质过氧化、铁死亡和抗氧化网络的功能和调节。我们还讨论了脂质过氧化和铁死亡的潜在进化作用。
