眼健康和疾病中的内质网应激和未折叠蛋白反应。
ER stress and unfolded protein response in ocular health and disease.
机构信息
Department of Pathology, University of California San Diego, La Jolla, CA, USA.
Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tübingen, Germany.
出版信息
FEBS J. 2019 Jan;286(2):399-412. doi: 10.1111/febs.14522. Epub 2018 Jun 20.
Abstract
The human eye is the organ that is able to react to light in order to provide sharp three-dimensional and colored images. Unfortunately, the health of the eye can be impacted by various stimuli that can lead to vision loss, such as environmental changes, genetic mutations, or aging. Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) signaling have been detected in many diverse ocular diseases, and chemical and genetic approaches to modulate ER stress and specific UPR regulatory molecules have shown beneficial effects in animal models of eye disease. This review highlights specific eye diseases associated with ER stress and UPR activity, based on a recent symposia exploring this theme.
摘要
人眼是能够对光做出反应以提供清晰的三维和彩色图像的器官。不幸的是，眼睛的健康可能会受到各种刺激的影响，导致视力丧失，如环境变化、基因突变或衰老。内质网（ER）应激和未折叠蛋白反应（UPR）信号已在许多不同的眼部疾病中被检测到，并且化学和遗传方法来调节 ER 应激和特定的 UPR 调节分子在眼部疾病的动物模型中显示出了有益的效果。这篇综述根据最近探讨这一主题的专题研讨会，突出了与 ER 应激和 UPR 活性相关的特定眼部疾病。
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