Aspelin P, Nilsson P E, Schmid-Schönbein H, Schröder S, Simon R
Department of Diagnostic Radiololgy, Malmö Allmänna Sjukhus, Sweden.
Acta Radiol Suppl. 1987;370:89-91.
The influence of four non-ionic contrast media and one ionic contrast medium was analyzed on red blood cell deformability in vitro. The newly synthesized non-ionic monomeric iopentol and dimeric iodixanol were compared with the currently used non-ionic monomers iopamidol and iohexol and the ionic monomeric diatrizoate at a constant hematocrit of 8%. The effect on red blood cell deformability was analyzed in 50% volume ratio solutions of both original hypertonic and isotonic contrast media solutions. The samples were studied in a red blood cell filtrometer through new Mynipore microsieves using an improved procedure of data processing. Diatrizoate induced significantly more red blood cell rigidification compared with all non-ionic contrast media solutions and normal blood. There was no difference between the investigated non-ionic contrast media, nor between the non-ionic contrast media and normal blood without additive.
分析了四种非离子型造影剂和一种离子型造影剂对体外红细胞变形性的影响。在血细胞比容恒定为8%的情况下，将新合成的非离子型单体碘海醇和二聚体碘克沙醇与目前使用的非离子型单体碘帕醇和碘海醇以及离子型单体泛影葡胺进行比较。在原始高渗和等渗造影剂溶液的50%体积比溶液中分析对红细胞变形性的影响。通过新的密理博微筛，采用改进的数据处理程序，在红细胞滤过仪中对样品进行研究。与所有非离子型造影剂溶液和正常血液相比，泛影葡胺诱导的红细胞僵化明显更多。所研究的非离子型造影剂之间以及非离子型造影剂与无添加剂的正常血液之间均无差异。
