Pakalapati Harshini, Chang Chih-Kai, Show Pau Loke, Arumugasamy Senthil Kumar, Lan John Chi-Wei
Department of Chemical and Environmental Engineering, Faculty of Engineering, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor Darul Ehsan, Malaysia; Biorefinery and Bioprocess Engineering Laboratory, Department of Chemical Engineering and Materials Science, Yuan Ze University, No. 135 Yuan-Tung Road, Chungli, Taoyuan 32003, Taiwan.
Biorefinery and Bioprocess Engineering Laboratory, Department of Chemical Engineering and Materials Science, Yuan Ze University, No. 135 Yuan-Tung Road, Chungli, Taoyuan 32003, Taiwan.
J Biosci Bioeng. 2018 Sep;126(3):282-292. doi: 10.1016/j.jbiosc.2018.03.016. Epub 2018 May 24.
Polyhydroxyalkanoates (PHA) are naturally occurring biopolymers, obtained from microorganisms. Properties like biodegradability and biocompatibility make PHA a part of today's commercial polymer industry. However, the production cost of PHA has been a great barrier to extend its application to large scale production. Substrates and usage of pure cultures constitute the main reason for its high production cost. On the other hand, rapid industrialization i.e., industrial sectors such as sugar, pulp and paper, fruit and food processing, dairies, slaughterhouses, and poultries, has resulted in the generation of the huge quantity of wastes. Consequently, becoming large source of environmental pollution and health hazard. This review emphasizes on the usage of various waste feedstocks obtained from industrial and agricultural industries as an alternate substrate for PHA production. As these waste materials are rich in organic material and also microbes, they can be the good starting material for PHA production. Additionally, advantages and economic importance of mixed cultures and also PHA applications are discussed. Future prospects and challenges in PHA production from waste feedstocks are also highlighted.
聚羟基脂肪酸酯（PHA）是天然存在的生物聚合物，由微生物产生。生物可降解性和生物相容性等特性使PHA成为当今商业聚合物行业的一部分。然而，PHA的生产成本一直是将其应用扩展到大规模生产的巨大障碍。纯培养物的底物和使用是其生产成本高昂的主要原因。另一方面，快速工业化，即制糖、纸浆和造纸、水果和食品加工、乳制品、屠宰场和家禽养殖等工业部门，产生了大量废物。因此，成为环境污染和健康危害的主要来源。本综述着重介绍了将从工农业获得的各种废弃原料用作PHA生产替代底物的情况。由于这些废料富含有机物质和微生物，它们可以成为PHA生产的良好起始材料。此外，还讨论了混合培养物的优势和经济重要性以及PHA的应用。还强调了利用废弃原料生产PHA的未来前景和挑战。
