Department of Gynecology, Clinical Institute of Gynecology, Obstetrics, and Neonatology, Hospital Clinic of Barcelona, Faculty of Medicine, University of Barcelona, Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Department of Hemotherapy and Hemostasis, Hospital Clinic of Barcelona, Faculty of Medicine, University of Barcelona, Barcelona, Spain.
J Minim Invasive Gynecol. 2019 Mar-Apr;26(3):450-455. doi: 10.1016/j.jmig.2018.05.014. Epub 2018 May 24.
To evaluate serial generation of microparticles (MPs) after laparoscopic stripping or CO laser vaporization in the surgical treatment of patients with ovarian endometrioma (OE).
A prospective, randomized, blinded, pilot study (Canadian Task Force classification I).
Tertiary care university hospital from December 2014 to July 2016.
Thirty women with unilateral OE undergoing laparoscopic surgery.
Patients were randomly selected to undergo either CO laser vaporization (L group) or laparoscopic stripping (S group) of OE.
Blood samples were collected before surgery and at 2 hours, 24 hours, 1 month, and 3 months after surgery. An MP generation curve after OE surgery was created. MP generation was greater in the S group than in the L group at all time points evaluated. The MP generation curve showed a significantly higher area under the curve after excisional surgery (p <.05).
The higher MP levels in the S group suggest an increased inflammation and procoagulant response after this procedure.
评估腹腔镜剥除术或 CO2 激光汽化术治疗卵巢子宫内膜异位症（OE）患者后微粒（MPs）的连续产生。
前瞻性、随机、双盲、初步研究（加拿大任务组分类 I）。
2014 年 12 月至 2016 年 7 月三级护理大学医院。
30 名单侧 OE 患者接受腹腔镜手术。
患者随机选择接受 CO2 激光汽化术（L 组）或腹腔镜剥除术（S 组）治疗 OE。
在手术前、手术后 2 小时、24 小时、1 个月和 3 个月采集血样。创建 OE 手术后 MPs 生成曲线。在所有评估的时间点，S 组的 MPs 生成量均高于 L 组。切除手术后 MPs 生成曲线下面积显著升高（p<.05）。
S 组 MPs 水平较高表明该手术术后炎症和促凝反应增加。
