Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University), 30# Gaotanyan Rd., Shapingba District, Chongqing 400038, China; Center of Translational Medicine, College of Pharmacy, Army Medical University (Third Military Medical University), 30# Gaotanyan Rd., Shapingba District, Chongqing 400038, China.
Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University), 30# Gaotanyan Rd., Shapingba District, Chongqing 400038, China; Center of Translational Medicine, College of Pharmacy, Army Medical University (Third Military Medical University), 30# Gaotanyan Rd., Shapingba District, Chongqing 400038, China.
Pharmacol Ther. 2018 Oct;190:159-172. doi: 10.1016/j.pharmthera.2018.05.009. Epub 2018 May 25.
In recent years, the rapid development of medical and pharmacological interventions has led to a steady decline in certain noncommunicable chronic diseases (NCDs), such as cancer. However, the overall incidence of cardiovascular diseases (CVDs) has not seemed to decline. CVDs have become even more prevalent in many countries and represent a global health threat and financial burden. An increasing number of epidemiological and experimental studies have demonstrated that maternal insults not only can result in birth defects but also can cause developmental functional defects that contribute to adult NCDs. In the current review, we provide an overview of evidence from both epidemiological investigations and experimental animal studies supporting the concept of developmental reprogramming of adult CVDs in offspring that have experienced prenatal inflammation exposure (PIE) during fetal development (PIE-programmed CVDs), a disease-causing event that has not been effectively controlled. This review describes the epidemiological observations, data from animal models, and related mechanisms for the pathogenesis of PIE-programmed CVDs. In addition, the potential therapeutic interventions of PIE-programmed CVDs are discussed. Finally, we also deliberate the need for future mechanistic studies and biomarker screenings in this important field, which creates a great opportunity to combat the global increase in CVDs by managing the adverse effects of inflammation for prepregnant and pregnant individuals who are at risk for PIE-programmed CVDs.
近年来，医学和药理学干预的快速发展导致某些非传染性慢性疾病（NCDs），如癌症的发病率稳步下降。然而，心血管疾病（CVDs）的总体发病率似乎并没有下降。心血管疾病在许多国家更为普遍，是全球健康威胁和财政负担。越来越多的流行病学和实验研究表明，母体损伤不仅会导致出生缺陷，还会导致发育功能缺陷，从而导致成年期的非传染性慢性疾病。在目前的综述中，我们提供了来自流行病学调查和实验动物研究的证据，这些证据支持了在胎儿发育过程中经历过产前炎症暴露（PIE）的后代中存在的成年 CVDs 发育重编程的概念（PIE 编程的 CVDs），这是一种尚未得到有效控制的致病事件。本综述描述了 PIE 编程的 CVDs 的流行病学观察、动物模型数据和相关发病机制。此外，还讨论了 PIE 编程的 CVDs 的潜在治疗干预措施。最后，我们还讨论了在这个重要领域进行未来机制研究和生物标志物筛选的必要性，这为通过管理有发生 PIE 编程的 CVDs 风险的孕妇和孕妇的炎症的不利影响，来对抗全球 CVDs 的增加提供了机会。
