Pateria Puraskar, Muwanwella Niroshan, Chai Ming, Venugopal Kannan
Department of Gastroenterology and Hepatology, Royal Perth Hospital, Perth, Western Australia, Australia.
Anatomical Pathology, PathWest Laboratory Medicine Western Australia, Nedlands, Western Australia, Australia.
BMJ Case Rep. 2018 May 26;2018:bcr-2018-225092. doi: 10.1136/bcr-2018-225092.
A 75-year-old retired teacher presents with dysphagia and weight loss for a duration of 6 months. Her gastroscopy showed two synchronous submucosal masses. A 7 cm polypoid mass was seen at the distal oesophagus, arising from a thick stalk and a 4 cm mass seen at the cardia. The biopsies showed high-grade sarcomatoid cancer. Staging CT scan and Positron Emission Tomography scan did not show any distant metastasis except a lesion in the rectum that was subsequently found to be tubulovillous adenoma on transanal excision. The patient was managed with Ivor Lewis oesophagectomy. The biopsies of resection specimen showed spindle cell/sarcomatoid carcinoma with a component of poorly differentiated neuroendocrine carcinoma in oesophageal tumour and a small component of conventional invasive squamous cell carcinoma in tumour at cardia. The patient recovered well after surgery. Since then, she has completed adjuvant chemoradiotherapy. No recurrence has been noted in 10 months follow-up.
一位75岁的退休教师出现吞咽困难和体重减轻6个月。她的胃镜检查显示有两个同步的黏膜下肿块。在食管远端可见一个7厘米的息肉样肿块,起源于粗蒂,在贲门处可见一个4厘米的肿块。活检显示为高级别肉瘤样癌。分期CT扫描和正电子发射断层扫描未显示任何远处转移,除了直肠的一个病变,经肛门切除后发现为管状绒毛状腺瘤。患者接受了Ivor Lewis食管切除术治疗。切除标本的活检显示食管肿瘤为梭形细胞/肉瘤样癌,伴有低分化神经内分泌癌成分,贲门肿瘤有一小部分为传统浸润性鳞状细胞癌。患者术后恢复良好。此后,她完成了辅助放化疗。在10个月的随访中未发现复发。