• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

与 Q 热疲劳综合征患者主诉相关的干扰素-γ 和 CXCL10 反应。

Interferon-γ and CXCL10 responses related to complaints in patients with Q fever fatigue syndrome.

机构信息

Radboud Expertise Center for Q fever, Department of Internal Medicine, Division of Infectious Diseases 463, Radboud University Medical Center, P.O. Box 9101, 6500, HB, Nijmegen, The Netherlands.

Department of Internal Medicine, Radboud University Medical Center, P.O. Box 9101, 6500, HB, Nijmegen, The Netherlands.

出版信息

Eur J Clin Microbiol Infect Dis. 2018 Jul;37(7):1385-1391. doi: 10.1007/s10096-018-3265-z. Epub 2018 May 26.

DOI:10.1007/s10096-018-3265-z
PMID:29804281
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6015096/
Abstract

Approximately 20% of patients with acute Q fever develop Q fever fatigue syndrome (QFS), a debilitating fatigue syndrome. This study further investigates the role of C. burnetii-specific IFNγ, but also IL-2, CXCL9, CXCL10, and CXLC11 production in QFS patients. C. burnetii-specific IFNy, IL-2, CXCL9, CXCL10, and CXCL11 production were tested in ex vivo stimulated whole blood of QFS patients who recovered from their complaints (n = 8), QFS patients with persisting complaints (n = 27), and asymptomatic Q fever seropositive controls (n = 10). With the exclusion of one outlier, stimulation with C. burnetii revealed significantly higher IFNy and CXCL10 production in QFS patients with persisting complaints (medians 288.0 and 176.0 pg/mL, respectively) than in QFS patients who recovered from their complaints (medians 93.0 and 85.5 pg/mL, respectively) (p = 0.041 and 0.045, respectively). No significant differences between groups were found for C. burnetii-specific IL-2, CXCL9, and CXCL11 production. These findings point towards a difference in cell-mediated immunity in QFS patients with persisting complaints compared to those who recovered from their complaints. Such a difference may aid to eventually diagnose QFS more objectively and might serve as an indicator of its underlying etiology.

摘要

约 20%的急性 Q 热患者会发展为 Q 热疲劳综合征（QFS），这是一种使人虚弱的疲劳综合征。本研究进一步调查了伯氏考克斯体特异性 IFNγ，以及 IL-2、CXCL9、CXCL10 和 CXCL11 产生在 QFS 患者中的作用。对已从症状中恢复的 QFS 患者（n=8）、持续存在症状的 QFS 患者（n=27）和无症状 Q 热血清阳性对照者（n=10）的体外刺激全血进行了 C. burnetii 特异性 IFNy、IL-2、CXCL9、CXCL10 和 CXCL11 产生的测试。排除一个离群值后，与已从症状中恢复的 QFS 患者（中位数分别为 93.0 和 85.5 pg/mL）相比，持续存在症状的 QFS 患者（中位数分别为 288.0 和 176.0 pg/mL）的 C. burnetii 刺激后 IFNy 和 CXCL10 产生明显更高（p=0.041 和 0.045）。对于 C. burnetii 特异性 IL-2、CXCL9 和 CXCL11 产生，各组之间无显著差异。这些发现表明，与已从症状中恢复的 QFS 患者相比，持续存在症状的 QFS 患者的细胞介导免疫存在差异。这种差异可能有助于最终更客观地诊断 QFS，并可能作为其潜在病因的指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6eab/6015096/ad0f3bd0cbca/10096_2018_3265_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6eab/6015096/ad0f3bd0cbca/10096_2018_3265_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6eab/6015096/ad0f3bd0cbca/10096_2018_3265_Fig1_HTML.jpg

相似文献

1
Interferon-γ and CXCL10 responses related to complaints in patients with Q fever fatigue syndrome.与 Q 热疲劳综合征患者主诉相关的干扰素-γ 和 CXCL10 反应。
Eur J Clin Microbiol Infect Dis. 2018 Jul;37(7):1385-1391. doi: 10.1007/s10096-018-3265-z. Epub 2018 May 26.
2
Altered interferon-γ response in patients with Q-fever fatigue syndrome.Q热疲劳综合征患者的干扰素-γ反应改变。
J Infect. 2016 Apr;72(4):478-85. doi: 10.1016/j.jinf.2016.01.004. Epub 2016 Jan 25.
3
CXCL9, a promising biomarker in the diagnosis of chronic Q fever.CXCL9是慢性Q热诊断中一种很有前景的生物标志物。
BMC Infect Dis. 2017 Aug 9;17(1):556. doi: 10.1186/s12879-017-2656-6.
4
Cytokine profiles in patients with Q fever fatigue syndrome.Q 热疲劳综合征患者的细胞因子谱。
J Infect. 2019 May;78(5):349-357. doi: 10.1016/j.jinf.2019.01.006. Epub 2019 Jan 23.
5
Cytokine dysregulation in the post-Q-fever fatigue syndrome.Q热后疲劳综合征中的细胞因子失调
QJM. 1998 Aug;91(8):549-60. doi: 10.1093/qjmed/91.8.549.
6
A combination of interferon-gamma and interleukin-2 production by Coxiella burnetii-stimulated circulating cells discriminates between chronic Q fever and past Q fever.贝氏柯克斯体刺激循环细胞产生的干扰素-γ和白细胞介素-2的组合可区分慢性 Q 热和既往 Q 热。
Clin Microbiol Infect. 2014 Jul;20(7):642-50. doi: 10.1111/1469-0691.12423. Epub 2013 Nov 18.
7
Objective cognitive performance and subjective complaints in patients with chronic Q fever or Q fever fatigue syndrome.慢性 Q 热或 Q 热疲劳综合征患者的客观认知表现和主观抱怨。
BMC Infect Dis. 2020 Jun 5;20(1):397. doi: 10.1186/s12879-020-05118-z.
8
Viable Coxiella burnetii Induces Differential Cytokine Responses in Chronic Q Fever Patients Compared to Heat-Killed Coxiella burnetii.活的贝氏考克斯体与热灭活的贝氏考克斯体相比，可诱导慢性 Q 热患者产生不同的细胞因子反应。
Infect Immun. 2018 Sep 21;86(10). doi: 10.1128/IAI.00333-18. Print 2018 Oct.
9
A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome.线粒体衍生肽人胰岛素和 MOTS-c 在 Q 热疲劳综合征和慢性疲劳综合征患者中的可能作用。
J Transl Med. 2019 May 14;17(1):157. doi: 10.1186/s12967-019-1906-3.
10
Specific interferon γ detection for the diagnosis of previous Q fever.针对既往 Q 热的诊断进行特定干扰素 γ 的检测。
Clin Infect Dis. 2013 Jun;56(12):1742-51. doi: 10.1093/cid/cit129. Epub 2013 Mar 5.

引用本文的文献

1
Role of Trained Immunity in Heath and Disease.训练有素的免疫在健康与疾病中的作用。
Curr Cardiol Rep. 2025 Jan 13;27(1):18. doi: 10.1007/s11886-024-02167-7.
2
Bulk RNA sequencing for analysis of post COVID-19 condition in adolescents and young adults.针对青少年和青年群体的新冠后遗症进行批量 RNA 测序分析。
J Transl Med. 2024 Mar 26;22(1):312. doi: 10.1186/s12967-024-05117-7.
3
Cytometry profiling of recall responses to in previously naturally exposed individuals reveals long-term changes in both adaptive and innate immune cellular compartments.

本文引用的文献

1
CXCL9, a promising biomarker in the diagnosis of chronic Q fever.CXCL9是慢性Q热诊断中一种很有前景的生物标志物。
BMC Infect Dis. 2017 Aug 9;17(1):556. doi: 10.1186/s12879-017-2656-6.
2
Effectiveness of Long-term Doxycycline Treatment and Cognitive-Behavioral Therapy on Fatigue Severity in Patients with Q Fever Fatigue Syndrome (Qure Study): A Randomized Controlled Trial.长期多西环素治疗和认知行为疗法对 Q 热疲劳综合征患者疲劳严重程度的影响（Qure 研究）：一项随机对照试验。
Clin Infect Dis. 2017 Apr 15;64(8):998-1005. doi: 10.1093/cid/cix013.
3
Altered interferon-γ response in patients with Q-fever fatigue syndrome.
对先前自然暴露个体中针对 的回忆反应进行细胞仪分析，揭示了适应性和固有免疫细胞区室的长期变化。
Front Immunol. 2023 Oct 11;14:1249581. doi: 10.3389/fimmu.2023.1249581. eCollection 2023.
4
Leflunomide/hydroxychloroquine combination therapy targets type I IFN-associated proteins in patients with Sjögren's syndrome that show potential to predict and monitor clinical response.来氟米特/羟氯喹联合治疗靶向干燥综合征患者的 I 型 IFN 相关蛋白，这些蛋白具有预测和监测临床反应的潜力。
RMD Open. 2023 Aug;9(3). doi: 10.1136/rmdopen-2023-002979.
5
Multi-omics examination of Q fever fatigue syndrome identifies similarities with chronic fatigue syndrome.Q热疲劳综合征的多组学研究揭示了其与慢性疲劳综合征的相似之处。
J Transl Med. 2020 Nov 26;18(1):448. doi: 10.1186/s12967-020-02585-5.
6
Long-Lasting Transcriptional Changes in Circulating Monocytes of Acute Q Fever Patients.急性Q热患者循环单核细胞中持久的转录变化
Open Forum Infect Dis. 2019 Jul 1;6(7). doi: 10.1093/ofid/ofz296.
7
A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome.线粒体衍生肽人胰岛素和 MOTS-c 在 Q 热疲劳综合征和慢性疲劳综合征患者中的可能作用。
J Transl Med. 2019 May 14;17(1):157. doi: 10.1186/s12967-019-1906-3.
Q热疲劳综合征患者的干扰素-γ反应改变。
J Infect. 2016 Apr;72(4):478-85. doi: 10.1016/j.jinf.2016.01.004. Epub 2016 Jan 25.
4
The health status of a village population, 7 years after a major Q fever outbreak.一次大规模Q热疫情爆发7年后一个村庄人口的健康状况。
Epidemiol Infect. 2016 Apr;144(6):1153-62. doi: 10.1017/S0950268815002472. Epub 2015 Nov 12.
5
CXCR3 ligands in disease and therapy.CXCR3 配体在疾病和治疗中的作用。
Cytokine Growth Factor Rev. 2015 Jun;26(3):311-27. doi: 10.1016/j.cytogfr.2014.11.009. Epub 2014 Nov 22.
6
Chronic Q fever in the Netherlands 5 years after the start of the Q fever epidemic: results from the Dutch chronic Q fever database.荷兰Q热疫情开始5年后的慢性Q热：来自荷兰慢性Q热数据库的结果
J Clin Microbiol. 2014 May;52(5):1637-43. doi: 10.1128/JCM.03221-13. Epub 2014 Mar 5.
7
A combination of interferon-gamma and interleukin-2 production by Coxiella burnetii-stimulated circulating cells discriminates between chronic Q fever and past Q fever.贝氏柯克斯体刺激循环细胞产生的干扰素-γ和白细胞介素-2的组合可区分慢性 Q 热和既往 Q 热。
Clin Microbiol Infect. 2014 Jul;20(7):642-50. doi: 10.1111/1469-0691.12423. Epub 2013 Nov 18.
8
Specific interferon γ detection for the diagnosis of previous Q fever.针对既往 Q 热的诊断进行特定干扰素 γ 的检测。
Clin Infect Dis. 2013 Jun;56(12):1742-51. doi: 10.1093/cid/cit129. Epub 2013 Mar 5.
9
Screening for Coxiella burnetii seroprevalence in chronic Q fever high-risk groups reveals the magnitude of the Dutch Q fever outbreak.对慢性 Q 热高危人群中柯克斯体血清流行率的筛查揭示了荷兰 Q 热爆发的规模。
Epidemiol Infect. 2013 Apr;141(4):847-51. doi: 10.1017/S0950268812001203. Epub 2012 Jun 13.
10
Relation between Q fever notifications and Coxiella burnetii infections during the 2009 outbreak in The Netherlands.2009 年荷兰 Q 热疫情期间的 Q 热通报与贝氏柯克斯体感染之间的关系。
Euro Surveill. 2012 Jan 19;17(3):20058.