Xie K J, Zhang W, Yuan J B, Zhou J, Lian Y Y, Fang J
Department of Anesthesiology, Zhejiang Caner Hospital, Hangzhou 310022, China.
Zhonghua Yi Xue Za Zhi. 2018 May 15;98(18):1430-1433. doi: 10.3760/cma.j.issn.0376-2491.2018.18.012.
To observe whether Ginkgo biloba extract (EGb761) can improve postoperative delirium in elderly patients. Eighty elderly patients undergoing tumor surgery at Zhejiang Cancer Hospital and complicated with postoperative delirium(POD) between June 2013 and July 2016 were randomly divided into treatment group (group A) and control group (group B) according to the random number table method. Patients in group A received ginkgo biloba extract (EGb761) drops oral treatment (3 times/d, 80 mg each time) in addition to oxygen inhalation and appeasement treatment. Patients in group B underwent routine oxygen inhalation and appeasement treatment. POD assessment was performed twice between the hours of 8: 00 am and 8: 00 pm daily after the diagnosis of POD. Observed indicators include sex ratio, age, body mass index (BMI), educated level, type of surgery, anesthesia method, duration of surgery, intraoperative mean arterial blood pressure, intraoperative blood loss, type of POD, visual analogue scale (VAS) scores when diagnosis of POD, the onset time of POD, initial RASS scores, duration of POD. A total of 80 patients with POD were enrolled, 23 patients were excluded for did not cooperate with the tests of POD or refused to participate in the study. Finally, 57 elderly patients completed the study, 29 patients in the medication group (A group) and 28 patients in the control group (B group). There was no significant difference in sex ratio, age, BMI, education level, operation type, anesthesia method, operation duration, intraoperative mean arterial pressure, intraoperative blood loss, POD type and VAS score (all >0.05). There was no significant difference between the two groups in POD onset time and initial RASS score (all >0.05). The duration of POD in group A and group B was 16 (16)h and 48 (35) h respectively, the difference was statistically significant (=161.500, <0.001). Ginkgo biloba extract (EGb761) can shorten the course of POD in elderly patients.
观察银杏叶提取物（EGb761）能否改善老年患者术后谵妄。选取2013年6月至2016年7月在浙江省肿瘤医院行肿瘤手术且并发术后谵妄（POD）的80例老年患者，按随机数字表法随机分为治疗组（A组）和对照组（B组）。A组患者在吸氧及安抚治疗基础上，加用银杏叶提取物（EGb761）滴剂口服治疗（每日3次，每次80mg）。B组患者行常规吸氧及安抚治疗。确诊POD后，每日上午8:00至晚上8:00之间对POD进行2次评估。观察指标包括性别比、年龄、体重指数（BMI）、受教育程度、手术类型、麻醉方式、手术时长、术中平均动脉压、术中出血量、POD类型、确诊POD时视觉模拟评分（VAS）、POD发病时间、初始RASS评分、POD持续时间。共纳入80例POD患者，23例因不配合POD测试或拒绝参与研究而被排除。最终，57例老年患者完成研究，用药组（A组）29例，对照组（B组）28例。两组在性别比、年龄、BMI、受教育程度、手术类型、麻醉方式、手术时长、术中平均动脉压、术中出血量、POD类型及VAS评分方面差异均无统计学意义（均>0.05）。两组在POD发病时间及初始RASS评分方面差异也无统计学意义（均>0.05）。A组和B组的POD持续时间分别为16（16）小时和48（35）小时，差异有统计学意义（=161.500，<0.001）。银杏叶提取物（EGb761）可缩短老年患者POD病程。
