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[癌症免疫疗法]

[Cancer immunotherapy].

作者信息

Kjeldsen Julie Westerlin, Donia Marco, Svane Inge Marie

出版信息

Ugeskr Laeger. 2018 May 21;180(21).

Abstract

Cancer immunotherapy takes advantage of the immune system to treat cancer. The checkpoint inhibitors have advanced the field of cancer treatment, but adoptive cell therapy and cancer vaccines also show promising results. The checkpoint inhibitors ipilimumab and later nivolumab/pembrolizumab have been standard therapy to patients with metastatic melanoma for several years. Today, the field is expanding, and other types of solid tumours have had checkpoint inhibitors applied to them, and more will follow. A portion of the patients develop immune-related adverse events, which should be handled by specialists.

摘要

癌症免疫疗法利用免疫系统来治疗癌症。检查点抑制剂推动了癌症治疗领域的发展,但过继性细胞疗法和癌症疫苗也显示出了有前景的结果。检查点抑制剂伊匹单抗以及后来的纳武单抗/派姆单抗已成为转移性黑色素瘤患者的标准疗法数年之久。如今,该领域正在不断扩展,其他类型的实体瘤也已应用了检查点抑制剂,而且更多的实体瘤也将陆续应用。一部分患者会出现免疫相关不良事件,应由专家进行处理。

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