血脑屏障修饰与化疗。介入神经放射学在恶性胶质瘤治疗中的应用。
Blood brain barrier modification and chemotherapy. Interventional neuroradiology in the treatment of malignant gliomas.
作者信息
Heimberger K, Samec P, Binder H, Podreka I, Reisner T, Deecke L, Horaczek A, Dittrich C, Steger G, Zimpfer M
机构信息
Department of Neurology, Vienna University Clinics, Austria.
出版信息
Acta Radiol Suppl. 1986;369:223-6.
Postoperative interventional neuroradiology was performed in patients with malignant gliomas to increase target efficacy of chemotherapy. In 8 glioma patients the blood brain or blood tumor barrier was reversibly opened by intraarterial injection of hyperosmolar fluid (Mannitol 25%). One additional patient had primary lymphoma of the central nervous system. During barrier modification chemotherapeutic agents were applied intraarterially and intravenously. A total of 22 blood brain barrier modification procedures have been carried out until now, ranging from one to five per patient. A presently continuing tumor regression or tumor progression free intervals have been noted in 5 patients. Therapeutic effects are being evaluated from repeated computed tomography and single photon emission computed tomography examinations.
对恶性胶质瘤患者进行术后介入神经放射学治疗以提高化疗的靶向疗效。在8例胶质瘤患者中，通过动脉内注射高渗液（25%甘露醇）可逆性地打开血脑屏障或血肿瘤屏障。另有1例患者患有中枢神经系统原发性淋巴瘤。在屏障修饰过程中，动脉内和静脉内应用化疗药物。到目前为止，共进行了22次血脑屏障修饰手术，每位患者进行1至5次。目前有5例患者出现持续的肿瘤消退或无肿瘤进展间期。通过重复计算机断层扫描和单光子发射计算机断层扫描检查评估治疗效果。
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