Lund University, P.O. Box 124, 221 00 Lund, Sweden; SuMo BIOMATERIALS, Chalmers University of Technology, 412 96 Gothenburg, Sweden.
SuMo BIOMATERIALS, Chalmers University of Technology, 412 96 Gothenburg, Sweden; School of Energy and Resources, University College London, 220 Victoria Square, Adelaide, SA, 5000, Australia; Future Industries Institute, University of South Australia, Mawson Lakes Campus, SA 5095, Australia.
Adv Colloid Interface Sci. 2018 Jun;256:48-64. doi: 10.1016/j.cis.2018.05.004. Epub 2018 May 25.
Films engineered to control the transport of liquids are widely used through society. Examples include barriers in packaging, wound care products, and controlled release coatings in pharmaceutics. When observed at the macroscopic scale such films commonly appear homogeneous, however, a closer look reveals a complex nano- and microstructure that together with the chemical properties of the different domains control the transport properties. In this review we compare and discuss macroscopic transport properties, measured using the straightforward, yet highly powerful technique "modified Ussing chambers", also denoted side-by-side diffusion cells, for a wide range of structured polymer films and composites. We also discuss and compare the macroscopic observations and conclusions on materials properties with that of lattice Boltzmann simulations of transport properties based on underlying material structure and chemistry. The survey of the field: (i) highlights the use and power of modified Ussing Chambers for determining liquid transport properties of polymer films, (ii) demonstrates the predictability in both directions between macroscopic observations of transport using modified Ussing chambers and structure-based simulations, and (iii) provides experimental and theoretical insights regarding the transport-determining properties of structured polymer films and composites.
用于控制液体传输的薄膜在社会中得到了广泛应用。例如，在包装、伤口护理产品和药物控制释放涂层中都有应用。当从宏观尺度观察时，这些薄膜通常看起来是均匀的，但仔细观察会发现它们具有复杂的纳米和微观结构，这些结构与不同区域的化学性质一起控制着传输性质。在这篇综述中，我们比较和讨论了使用简单但非常强大的技术“改良 Ussing 室”（也称为并排扩散池）测量的各种结构化聚合物薄膜和复合材料的宏观传输性质。我们还讨论和比较了基于材料结构和化学的格子玻尔兹曼模拟运输性质的宏观观察和结论。对这一领域的调查：（i）突出了改良 Ussing 室在确定聚合物薄膜液体传输性质方面的用途和优势；（ii）展示了使用改良 Ussing 室进行宏观传输观察和基于结构的模拟之间的双向可预测性；（iii）提供了有关结构化聚合物薄膜和复合材料的传输决定性质的实验和理论见解。
