Vlajkovic S, Zwetnow N N, Thuomas K A, Bergström K, Pontén U, Nilsson P
Division of Experimental Neurosurgery, Rikshospitalet, University of Oslo, Norway.
Acta Radiol Suppl. 1986;369:353-5.
Sequential magnetic resonance imaging (MRI) was performed to correlate signs of herniation and increase in local brain tissue water content with continuous changes in vital physiologic parameters during progressive water intoxication in anaesthetized dogs. The intracranial pressure increase ultimately resulted in respiratory and cardiac arrest. MRI concomitantly showed an increase in local brain water content starting and dominating in the cerebral cortex but progressing to all parts of the central nervous system. The late appearance of transtentorial pressure gradients and of brain herniation suggests that development of cerebral edema occurs in at least two stages, an intracellular osmotic edema appearing first, being followed by an ischemic edema related to a progressive decrease in local perfusion pressure.
对麻醉犬进行渐进性水中毒期间，通过连续磁共振成像（MRI）将脑疝体征和局部脑组织含水量增加与重要生理参数的持续变化相关联。颅内压升高最终导致呼吸和心脏骤停。MRI同时显示局部脑含水量增加，始于大脑皮层并以其为主，但随后发展至中枢神经系统的所有部位。小脑幕切迹压力梯度和脑疝的晚期出现表明脑水肿的发展至少分为两个阶段，首先出现细胞内渗透性水肿，随后是与局部灌注压逐渐降低相关的缺血性水肿。
