Zwetnow N N, Vlajkovic S, Thuomas K A, Bergström K, Pontén U, Nilsson P
Division of Experimental Neurosurgery, Rikshospitalet, University of Oslo, Norway.
Acta Radiol Suppl. 1986;369:356-9.
Continuous recording of vital physiologic parameters and magnetic resonance imaging were performed during progressive extradural bleeding in spontaneously ventilated anesthetized dogs. The volume of the bleeding could exceed the intracranial volume by 500 per cent due to the formation of an extradural arteriovenous shunt. The rate of hematoma growth was dependent on the area of stripped dura. Midline shift, herniation and lateral ventricle compression occurred early, corresponding to changes in vital parameters. Local brain water increased non-linearly with white matter preceding gray matter. Water increase started first in the ipsilateral hemisphere followed by the contralateral hemisphere, brain stem and cerebellum. The correlation between local tissue water increase and local perfusion pressure supports the notion of an ischemic brain edema being formed during an extradural bleeding.
在自主呼吸的麻醉犬硬膜外进行渐进性出血期间，对重要生理参数进行连续记录，并进行磁共振成像。由于硬膜外动静脉分流的形成，出血量可能超过颅内体积的500%。血肿生长速率取决于硬脑膜剥离面积。中线移位、疝形成和侧脑室受压出现较早，与生命参数的变化相对应。局部脑含水量呈非线性增加，白质先于灰质。含水量增加首先发生在同侧半球，随后是对侧半球、脑干和小脑。局部组织含水量增加与局部灌注压之间的相关性支持了硬膜外出血期间形成缺血性脑水肿的观点。
