Applied Organic Chemistry Department, National Research Centre, Scopus Affiliation ID 60014618, 33 EL Buhouth St., Dokki, Giza, 12622, Egypt.
Pretreatment and Finishing of Cellulosic Fibers, Textile Research Division, National Research Centre, Scopus Affiliation ID 60014618, 33 EL Buhouth St., Dokki, Giza, 12622, Egypt.
Carbohydr Polym. 2018 Sep 1;195:460-467. doi: 10.1016/j.carbpol.2018.04.122. Epub 2018 May 1.
Hemodialysis is one of the earliest artificial kidney systems, which removes uremic toxins through using a semipermeable porous membrane. Current report focuses on designation of metal organic framework (MOF) based zirconium@cotton fabric composite and its application in kidney dialysis. UiO-66-(COOH) as MOF material was directly grown within cotton fabric. Fabric was firstly reacted with benzene tetra carboxylic acid forming ester and then Zr was interacted with the free carboxylic groups in the formed ester to produce UiO-66-(COOH)@cotton fabric composite. The obtained composite was characterized by using electron microscope, X-ray diffraction, infrared spectroscopy and colorimetric data. After modification with MOF, fabric was acquired yellowish color. The prepared composite was used in potential kidney application through studying the removal of creatinine from mimic blood. The maximum adsorption capacity of creatinine was 113.6 and 192.3-212.8 mg/g for pristine fabric and UiO-66-(COOH)@fabric composite, respectively. From adsorption data, creatinine adsorption onto composite was followed to pseudo-second order kinetic model and Langmuir isotherm profile. After three regeneration cycles, the applied composite still achieved substantial adsorption capacity by removing of 82% from creatinine. UiO-66-(COOH)@cotton could be considered as successful adsorbent capable of removing creatinine from blood with good reusability, which can be applied in kidney dialysis.
血液透析是最早的人工肾系统之一，它通过使用半透多孔膜来清除尿毒症毒素。本报告重点介绍了基于金属有机骨架（MOF）的锆@棉织物复合材料的设计及其在肾脏透析中的应用。UiO-66-(COOH) 作为 MOF 材料直接在棉织物内生长。首先，织物与苯四羧酸反应形成酯，然后 Zr 与形成的酯中的游离羧酸基团相互作用，生成 UiO-66-(COOH)@棉织物复合材料。通过电子显微镜、X 射线衍射、红外光谱和比色数据对所得复合材料进行了表征。经过 MOF 修饰后，织物呈黄色。通过研究模拟血液中肌酸酐的去除，将制备的复合材料用于潜在的肾脏应用。原始织物和 UiO-66-(COOH)@织物复合材料对肌酸酐的最大吸附容量分别为 113.6 和 192.3-212.8mg/g。从吸附数据来看，肌酸酐的吸附符合准二级动力学模型和 Langmuir 等温线。经过三个再生循环后，应用的复合材料仍能通过去除 82%的肌酸酐来实现高吸附容量。UiO-66-(COOH)@棉可以被认为是一种成功的吸附剂，能够从血液中去除肌酸酐，具有良好的可重复使用性，可应用于肾脏透析。
