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通过固定化金属有机框架锚定的葡聚糖凝胶珠从模拟血液中高效吸附尿毒症毒素

Efficient uremic toxins adsorption from simulated blood by immobilization of metal organic frameworks anchored Sephadex beads.

作者信息

Abdelhameed Reda M, El-Shahat Mahmoud, Hegazi Bahira, Abdel-Gawad Hassan

机构信息

Applied Organic Chemistry Department, Chemical Industries Research Institute, National Research Centre, Scopus affiliation ID 60014618, 33 EL Buhouth St. , Dokki, Giza, 12622, Egypt.

Photochemistry Department, Chemical Industries Research Institute, National Research Centre, Scopus affiliation ID 60014618, 33 EL Buhouth St., Dokki, Giza, 12622, Egypt.

出版信息

Sci Rep. 2025 Mar 20;15(1):9667. doi: 10.1038/s41598-025-92492-w.

DOI:10.1038/s41598-025-92492-w
PMID:40113799
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11926176/
Abstract

The current study outlines the removal of Creatinine, p-Cresol sulfate, and Hippuric acid from simulated blood using three new granules: Fe-BTC@Sephadex, Cu-BTC@Sephadex, and Co-BTC@Sephadex. Beads were used to adsorbed toxic chemicals, and the effects of various experimental parameters were examined in the adsorption optimization process. The framework's adsorption isotherms were explained by the application of the Freundlich and Langmuir models. The kinetics of adsorption is represented by a pseudo-first and second-order equation. The morphology and structure of the Fe-BTC@ Sephadex, Co-BTC@ Sephadex, and Cu-BTC@Sephadex beads were investigated using Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and X-ray diffraction (XRD). The adsorption capacities for creatinine were 545.69, 339.76, and 189.88 mg/g for Fe-BTC@ Sephadex, Cu-BTC@ Sephadex, and Co-BTC@ Sephadex, respectively, according to the results; the corresponding adsorption capacities for hippuric acid were 323.78, 206.79, and 68.059 mg/g, and the maximum adsorption capacities for p-Cresol sulfate were 122.65, 71.268, and 40.347 mg/g, respectively. These were, in fact, promising findings that have implications for an industrial-scale transportable artificial kidney.

摘要

当前研究概述了使用三种新型颗粒

Fe-BTC@葡聚糖凝胶、Cu-BTC@葡聚糖凝胶和Co-BTC@葡聚糖凝胶从模拟血液中去除肌酐、对甲酚硫酸盐和马尿酸。使用珠子吸附有毒化学物质，并在吸附优化过程中考察了各种实验参数的影响。通过应用Freundlich和Langmuir模型解释了该框架的吸附等温线。吸附动力学由拟一级和二级方程表示。使用傅里叶变换红外光谱（FT-IR）、扫描电子显微镜（SEM）和X射线衍射（XRD）研究了Fe-BTC@葡聚糖凝胶、Co-BTC@葡聚糖凝胶和Cu-BTC@葡聚糖凝胶珠子的形态和结构。结果表明，Fe-BTC@葡聚糖凝胶、Cu-BTC@葡聚糖凝胶和Co-BTC@葡聚糖凝胶对肌酐的吸附容量分别为545.69、339.76和189.88mg/g；对马尿酸的相应吸附容量分别为323.78、206.79和68.059mg/g，对甲酚硫酸盐的最大吸附容量分别为122.65、71.268和40.347mg/g。实际上，这些都是很有前景的发现，对工业规模的可移动人工肾具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae2d/11926176/49ce6bbd9374/41598_2025_92492_Fig10_HTML.jpg
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