Sayin Murat, Gurgen Gulsen Seren, Sayin Sevgi Sıdıka, Guvenc Gonul, Yuceer Nurullah
Izmir Katip Celebi University, School of Medicine, Department of Neurosurgery, Izmir, Turkey.
Turk Neurosurg. 2019;29(1):106-109. doi: 10.5137/1019-5149.JTN.23431-18.1.
To investigate the impact of rizatriptan on neural tube development using early chick embryos as a model organism.
A total of 36 pathogen-free Leghorn chicken eggs were selected and categorized in three groups: sham, therapeutic, and supra-therapeutic. After 24 hours, the eggs were opened and injected with sterile drugs, and then reclosed using plastic tape. After a period of 72 hours, the eggs were opened and assessed using the Hamburger-Hamilton chick embryology classification method. TUNEL staining was used to identify apoptosis, and hematoxylin-eosin staining was used to investigate neural tube closure.
Treatment with rizatriptan significantly slowed down neural tube development. The supra-therapeutic group showed neural tube closure defects.
Rizatriptan had a negative effect on neural tube closure. Further research is needed to identify a safe and effective drug for treating migraines during pregnancy.
以早期鸡胚作为模式生物，研究利扎曲普坦对神经管发育的影响。
共选取36枚无特定病原体的来航鸡鸡蛋，分为三组：假手术组、治疗组和超治疗组。24小时后，打开鸡蛋并注射无菌药物，然后用塑料胶带重新封闭。72小时后，打开鸡蛋并使用汉堡-汉密尔顿鸡胚胎学分类方法进行评估。TUNEL染色用于鉴定细胞凋亡，苏木精-伊红染色用于研究神经管闭合情况。
利扎曲普坦治疗显著减缓了神经管发育。超治疗组出现神经管闭合缺陷。
利扎曲普坦对神经管闭合有负面影响。需要进一步研究以确定一种在孕期治疗偏头痛安全有效的药物。
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