Department of Bionanosystem Engineering Graduate School, Chonbuk National University, Jeonju City, Republic of Korea.
Division of Mechanical Design Engineering, Chonbuk National University, Jeonju City, Republic of Korea.
Sci Rep. 2016 Sep 20;6:33594. doi: 10.1038/srep33594.
This study reports on an intelligent composite hydrogel with both pH-dependent drug release in a cancer environment and heat generation based on NIR laser exposure, for the combined application of photothermal therapy (PTT) and multidrug chemotherapy. For the first time in the literature, Dopamine nanoparticle (DP) was incorporated as a highly effective photothermal agent as well as anticancer drug, bortezomib (BTZ) carrier inside a stimuli responsive pNIPAAm-co-pAAm hydrogel. When light is applied to the composite hydrogel, DP nanoparticle absorbs the light, which is dissipated locally as heat to impact cancer cells via hyperthermia. On the other hand, facile release of the anticancer drug BTZ from the surface of DP encapsulated hydrogel could be achieved due to the dissociation between catechol groups of DP and the boronic acid functionality of BTZ in typical acidic cancer environment. In order to increase the synergistic effect by dual drug delivery, Doxorubicin (DOXO) were also loaded to pNIPAAm-co-pAAm/DP-BTZ hydrogel and the effect of monotherapy as well as combined therapy were detailed by a complete characterization. Our results suggest that these mussel inspired nanocomposite with excellent heating property and controllable multidrug release can be considered as a potential material for cancer therapy.
本研究报告了一种智能复合水凝胶，该水凝胶在癌症环境中具有 pH 依赖性药物释放功能，并能在近红外激光照射下产生热量，可用于光热疗法（PTT）和多药化疗的联合应用。文献中首次将多巴胺纳米粒子（DP）作为一种高效的光热剂和硼替佐米（BTZ）载体，掺入到对刺激响应的 pNIPAAm-co-pAAm 水凝胶中。当光照射到复合水凝胶上时，DP 纳米粒子吸收光，光被局部耗散为热量，通过热疗来影响癌细胞。另一方面，由于 DP 的邻苯二酚基团与 BTZ 的硼酸官能团在典型的酸性癌症环境中分离，因此可以从 DP 封装的水凝胶表面轻易地释放出抗癌药物 BTZ。为了通过双重药物输送来提高协同作用，还将阿霉素（DOXO）负载到 pNIPAAm-co-pAAm/DP-BTZ 水凝胶上，并通过全面的特征描述详细研究了单药治疗和联合治疗的效果。我们的结果表明，这种具有优异加热性能和可控制的多药物释放功能的贻贝启发式纳米复合材料，可以被视为癌症治疗的一种有潜力的材料。
