a Pulmonary Division , Heart Institute (InCor) do Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo , São Paulo , Brazil.
b Pneumology Department , Centro Hospitalar de Leiria , Leiria , Portugal.
Expert Rev Respir Med. 2018 Jul;12(7):569-584. doi: 10.1080/17476348.2018.1481392. Epub 2018 Jun 14.
In recent years, there has been an increasing number of clinical trials investigating the effect of pharmacological treatments on patients with bronchiectasis. Areas covered: This review provides an overview of current drugs used in bronchiectasis patients as well as those that could make a future contribution to the management of this disease. Expert commentary: Bronchiectasis is a very heterogeneous disease, so it can be studied from a phenotypic standpoint and its pathophysiological mechanisms (endotypes) can be defined. This provides an interesting field of research as it enables the identification of patients suitable for inclusion in specific clinical trials on new drugs.
近年来，越来越多的临床试验研究了药物治疗对支气管扩张症患者的影响。
本文综述了目前用于支气管扩张症患者的药物，以及那些可能对该疾病的治疗做出未来贡献的药物。
支气管扩张症是一种非常异质性的疾病，因此可以从表型角度进行研究，并确定其病理生理机制（内型）。这为研究提供了一个有趣的领域，因为它能够识别适合纳入新药物特定临床试验的患者。
