Frederiek van den Bos, HagaHospital, department of internal medicine. Leyweg 275, 2545 CH, The Haque, The Netherlands, 0031-70-2102917.
J Nutr Health Aging. 2018;22(6):639-644. doi: 10.1007/s12603-018-1039-z.
Although the incidences of osteoporosis and atherosclerosis increase with age, there is growing evidence that the coincidental occurrence of both diseases may be independent of age. In general, studies in men are scarce and results are inconsistent.
to investigate the relationship between atherosclerosis and bone mineral density, and the influence of insulin sensitivity and low grade inflammation on this relationship in 332 men without CVD.
Aortic Pulse wave velocity (PWV), augmentation index (AIX) and measurements of carotid intima media thickness (CIMT) were assessed. BMD measurements were performed with dual-X-ray absorptiometry (DEXA), subcutaneous fat by ultrasonography. Serum concentrations of lipids, hsCRP, glucose and insulin were measured. Insulin sensitivity was calculated by use of the quantitative insulin sensitivity (QUICKI). We used multivariate linear regression models to examine the association of hsCRP, insulin sensitivity, PWV, Aix, CIMT with BMD.
A higher CIMT was significantly associated with higher BMD after multivariate adjustment (ß 99.7; p=0.02). Further adjustment for weight attenuated the estimates towards non-significant. No association was found between PWV or AIX and BMD. Lower insulin sensitivity was associated with higher BMD (ß -645.1; p<0.01). After adjustment for weight this association was no longer significant. A similar effect was seen for the association between hsCRP and BMD.
In this population of healthy, non-obese, men without a history of cardiovascular disease the positively association between cardiovascular parameters and BMD was mainly explained by weight, suggesting that in this population weight plays a protective role in the development of osteoporosis.
尽管骨质疏松症和动脉粥样硬化的发病率随着年龄的增长而增加，但越来越多的证据表明，这两种疾病的同时发生可能与年龄无关。一般来说，男性的研究较少，结果也不一致。
在 332 名无 CVD 的男性中，研究动脉粥样硬化与骨密度之间的关系，以及胰岛素敏感性和低度炎症对这种关系的影响。
评估主动脉脉搏波速度（PWV）、增强指数（AIX）和颈动脉内膜中层厚度（CIMT）的测量值。使用双能 X 线吸收法（DEXA）进行骨密度测量，使用超声进行皮下脂肪测量。测量血脂、hsCRP、血糖和胰岛素的血清浓度。使用定量胰岛素敏感性指数（QUICKI）计算胰岛素敏感性。我们使用多元线性回归模型来研究 hsCRP、胰岛素敏感性、PWV、AIX 和 CIMT 与 BMD 的相关性。
在多元调整后，较高的 CIMT 与较高的 BMD 显著相关（β 99.7；p=0.02）。进一步调整体重后，估计值趋于不显著。PWV 或 AIX 与 BMD 之间没有关联。较低的胰岛素敏感性与较高的 BMD 相关（β -645.1；p<0.01）。调整体重后，这种关联不再显著。hsCRP 与 BMD 之间的关联也存在类似的影响。
在这个没有心血管疾病病史的健康、非肥胖男性人群中，心血管参数与 BMD 之间的正相关主要由体重解释，这表明在这个人群中，体重在骨质疏松症的发展中起着保护作用。
