Anagnostis P, Karagiannis A, Kakafika A I, Tziomalos K, Athyros V G, Mikhailidis D P
Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Greece.
Osteoporos Int. 2009 Feb;20(2):197-207. doi: 10.1007/s00198-008-0648-5. Epub 2008 May 29.
Osteoporosis and atherosclerosis, two multifactorial and degenerative entities, are major public health problems. These diseases accompany the aging process and share common risk factors. Furthermore, several common pathophysiological factors have been suggested. These include similar molecular pathways involving bone and vascular mineralization, estrogen deficiency, parathyroid hormone, homocysteine, lipid oxidation products, inflammatory process, as well as vitamin D and K. Moreover, the use of statins, biphosphonates, beta-blockers and experimental dual-purpose therapies based on the biological linkage of the above entities may simultaneously benefit bone loss and vascular disease. This review considers a potential link between osteoporosis and atherosclerosis beyond aging. These common factors may lead to appropriate treatment strategies.
骨质疏松症和动脉粥样硬化是两种多因素的退行性疾病，是主要的公共卫生问题。这些疾病伴随衰老过程并具有共同的风险因素。此外，有人提出了一些共同的病理生理因素。这些因素包括涉及骨骼和血管矿化、雌激素缺乏、甲状旁腺激素、同型半胱氨酸、脂质氧化产物、炎症过程以及维生素D和K的相似分子途径。此外，使用他汀类药物、双膦酸盐、β受体阻滞剂以及基于上述疾病生物学联系的实验性两用疗法可能会同时有益于骨质流失和血管疾病。本综述探讨了骨质疏松症和动脉粥样硬化之间超越衰老的潜在联系。这些共同因素可能会带来合适的治疗策略。
