Victor M
Int J Neurol. 1987;21-22:51-7.
This discussion has been concerned with one small corner of the anatomy of memory, namely, with the role of mammillary body lesions in the causation of the Korsakoff amnesic state. Clinical-pathologic studies, both our own (of alcoholics with the Wernicke-Korsakoff syndrome) and those of others (in patients with thalamic infarctions and neoplasms) provide unambiguous evidence that medial thalamic lesions, without additional lesions of the mammillary bodies, are quite sufficient to produce a severe and enduring amnesic state. Behavioral abnormalities in animals, insofar as they can be equated with a defect in retentive memory, tend to substantiate the observations in humans.
本讨论一直关注记忆解剖学的一个小角落，即乳头体病变在柯萨科夫遗忘状态病因中的作用。临床病理研究，包括我们自己对（患有韦尼克-柯萨科夫综合征的酗酒者）的研究以及其他人对（丘脑梗死和肿瘤患者）的研究，都提供了明确的证据，表明内侧丘脑病变，在没有乳头体额外病变的情况下，足以产生严重且持久的遗忘状态。动物的行为异常，就其可等同于记忆保持缺陷而言，往往证实了人类的观察结果。
