Denby C E, Vann S D, Tsivilis D, Aggleton J P, Montaldi D, Roberts N, Mayes A R
School of Psychological Sciences, Manchester, England.
AJNR Am J Neuroradiol. 2009 Apr;30(4):736-43. doi: 10.3174/ajnr.A1424. Epub 2009 Jan 22.
Patients who have had a colloid cyst removed from the third ventricle sometimes experience some difficulty with day-to-day memory. This study provided quantitative MR imaging volume measures of 1 structure potentially responsible for mnemonic problems, the mammillary bodies. Additional volume estimates in structures connected to the mammillary bodies sought to determine the specificity of any atrophy.
Volume estimates of the mammillary bodies were performed on 38 patients after surgical removal of colloid cysts and 20 control subjects by the application of stereologic volume-estimation techniques. For the mammillary body measures, 2 groups of MR images were assessed (0.8- and 1.0-mm section thickness) to compare the sensitivity of each imaging sequence for detecting any atrophy. Other structures associated with memory processes, such as the hippocampus and fornix, were also assessed quantitatively to determine whether there was a correlation between mammillary body damage and atrophy in connecting structures.
Our investigations established the superiority of 0.8-mm-volume scans over standard isotropic 1.0-mm-thick-volume scans for mammillary body assessments. Comparisons with 20 age-matched controls revealed that patients with colloid cysts frequently showed significant mammillary body atrophy (mean volume of colloid cysts, 0.037 cm(3) right and 0.038 cm(3) left; control subjects, 0.069 cm(3) right and 0.067 cm(3) left). In fact, every patient had a mammillary body volume below the control mean, and the majority of patients had a volume decrease of >1 SD (82% right, 74% left). Mammillary body volumes correlated with fornix volumes in the same patient group.
Our results reveal the frequent presence of mammillary body atrophy in patients with surgical removal of colloid cysts and indicate that this atrophy is partly due to a loss of temporal lobe projections in the fornix.
从第三脑室切除胶体囊肿的患者有时在日常记忆方面会遇到一些困难。本研究提供了对1个可能导致记忆问题的结构——乳头体的定量磁共振成像体积测量。对与乳头体相连的结构进行额外的体积估计，以确定任何萎缩的特异性。
采用体视学体积估计技术，对38例手术切除胶体囊肿的患者和20例对照者进行乳头体体积估计。对于乳头体测量，评估了2组磁共振图像（切片厚度分别为0.8毫米和1.0毫米），以比较每个成像序列检测任何萎缩的敏感性。还对与记忆过程相关的其他结构，如海马体和穹窿进行了定量评估以确定乳头体损伤与连接结构萎缩之间是否存在相关性。
我们的研究确定了0.8毫米体积扫描在乳头体评估方面优于标准各向同性1.0毫米厚体积扫描。与20名年龄匹配的对照者相比，发现胶体囊肿患者经常出现明显的乳头体萎缩（胶体囊肿平均体积，右侧0.037立方厘米，左侧0.038立方厘米；对照者，右侧0.069立方厘米，左侧0.067立方厘米）。事实上，每个患者的乳头体体积均低于对照者平均值，且大多数患者的体积减少超过1个标准差（右侧82%，左侧74%）。在同一患者组中，乳头体体积与穹窿体积相关。
我们的结果显示，手术切除胶体囊肿的患者经常存在乳头体萎缩，表明这种萎缩部分是由于穹窿中颞叶投射的丧失。
