尖锐轮廓的θ波是原发性视皮质中 ponto-geniculo-occipital 波的人类对应物。

Sharply contoured theta waves are the human correlate of ponto-geniculo-occipital waves in the primary visual cortex.

机构信息

Montreal Neurological Institute and Hospital, McGill University, 3801 University Street, Montreal H3A 2B4, Quebec, Canada; Department of Medicine and Center for Neuroscience Studies, Queen's University, 18 Stuart Street, Kingston K7L 2V7, Ontario, Canada.

Montreal Neurological Institute and Hospital, McGill University, 3801 University Street, Montreal H3A 2B4, Quebec, Canada.

出版信息

Clin Neurophysiol. 2018 Aug;129(8):1526-1533. doi: 10.1016/j.clinph.2018.04.605. Epub 2018 Apr 27.

DOI:10.1016/j.clinph.2018.04.605

PMID:29807231

Abstract

OBJECTIVE

Ponto-geniculo-occipital (PGO) waves occurring along the visual axis are one of the hallmarks of REM sleep in experimental animals. In humans, direct evidence is scarce. There is no systematic study of PGO waves in the primary visual cortex.

METHODS

Eleven epilepsy patients undergoing combined intracranial EEG/polysomnography had 71 channels recording physiological EEG activity from various cortical areas; seven channels recorded from the primary visual cortex. An equal number of 4-s phasic and tonic REM segments were selected. Patterns consistent with PGO waves were visually analyzed in both states in the primary visual cortex. Spectral analysis compared activity in the primary visual cortex with the remaining cortical areas.

RESULTS

Visual inspection revealed an increase in sharply contoured theta waves (duration: 150-250 ms) in the primary visual cortex during phasic as compared to tonic REM sleep. Spectral analysis confirmed a 32% increase in mean absolute theta power during phasic versus tonic REM sleep (p corrected = 0.014).

CONCLUSION

No classical PGO waves, but sharply contoured theta waves were found in the human primary visual cortex during phasic as opposed to tonic REM sleep.

SIGNIFICANCE

This research suggests that sharply contoured theta waves are the human correlate of PGO waves described in experimental animal models.

摘要

目的

沿视觉轴发生的桥脑膝状体枕叶（PGO）波是实验动物 REM 睡眠的标志之一。在人类中，直接证据很少。目前还没有对初级视觉皮层中的 PGO 波进行系统研究。

方法

11 名接受颅内 EEG/多导睡眠图联合检查的癫痫患者有 71 个通道记录来自不同皮质区域的生理 EEG 活动；其中 7 个通道记录来自初级视觉皮层。选择了数量相等的 4 秒相和紧张 REM 段。在初级视觉皮层中对这两种状态下的视觉分析发现与 PGO 波一致的模式。频谱分析比较了初级视觉皮层与其余皮质区域的活动。