Moyano M C, Gázquez A, Redondo E, Roncero V
Department of Histology and Pathology, Faculty of Veterinary, University of Extremadura, Cáceres, Spain.
Histol Histopathol. 1987 Jul;2(3):265-71.
The aim of this study was to examine the structural, ultrastructural and morphometric alterations which take place in the contralateral kidneys of rats with experimental unilateral hydronephrosis. 20 Wistar rats weighing 250 g., affected by a process of unilateral hydronephrosis following the ligature of the ureter, were used; these rats were then killed 40, 50, 60, or 70 days after the ligature. Among the perceived alterations, were immunoglobulin G deposits shown by positive immunoperoxidase reaction and increase in the size of the glomerular and corpuscle from around the fortieth day, and structural alterations that included the pedicles, electrondense deposits in the podocytes and pseudogranular structures in the basal membrane of the capillary.
本研究的目的是检查实验性单侧肾积水大鼠对侧肾脏发生的结构、超微结构和形态测量学改变。选用20只体重250克的Wistar大鼠，在结扎输尿管后发生单侧肾积水；然后在结扎后40、50、60或70天处死这些大鼠。在观察到的改变中，有通过免疫过氧化物酶阳性反应显示的免疫球蛋白G沉积，从大约第40天起肾小球和肾小体大小增加，以及包括足细胞、足细胞内电子致密沉积物和毛细血管基底膜中的假颗粒结构在内的结构改变。
