Institute for Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology, and Immunology, Medical University of Vienna, Austria.
School of Engineering, Cardiff University, Cardiff, Wales, United Kingdom.
Trends Parasitol. 2018 Jul;34(7):576-589. doi: 10.1016/j.pt.2018.04.007. Epub 2018 May 26.
The microaerophilic parasites Entamoeba histolytica, Trichomonas vaginalis, and Giardia lamblia jointly cause hundreds of millions of infections in humans every year. Other microaerophilic parasites such as Tritrichomonas foetus and Spironucleus spp. pose a relevant health problem in veterinary medicine. Unfortunately, vaccines against these pathogens are unavailable, but their microaerophilic lifestyle opens opportunities for specifically developed chemotherapeutics. In particular, their high sensitivity towards oxygen can be exploited by targeting redox enzymes. This review focusses on the redox pathways of microaerophilic parasites and on drugs, either already in use or currently in the state of development, which target these pathways.
微需氧寄生虫溶组织内阿米巴、阴道毛滴虫和蓝氏贾第鞭毛虫每年在人类中共同引发数亿感染。其他微需氧寄生虫，如胎儿三毛滴虫和旋毛形线虫等，在兽医医学中构成相关的健康问题。不幸的是，针对这些病原体的疫苗尚不可用，但它们的微需氧生活方式为专门开发的化疗药物提供了机会。特别是，通过针对氧化还原酶，可以利用它们对氧气的高度敏感性。这篇综述重点介绍了微需氧寄生虫的氧化还原途径以及针对这些途径的现有或正在开发中的药物。
