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一个大型5级可移动性主动脉弓动脉粥样硬化斑块:脑血管意外的病因。

A Large Grade 5 Mobile Aortic Arch Atheromatous Plaque: Cause of Cerebrovascular Accident.

作者信息

Alvarez Chikezie, Aslam Hafiz Muhammad, Wallach Sara, Mustafa Muhammad U

机构信息

Seton Hall University, St. Francis Medical Center, Trenton, NJ, USA.

Capital Health Center, Hamilton, NJ, USA.

出版信息

Case Rep Med. 2018 Apr 1;2018:5134309. doi: 10.1155/2018/5134309. eCollection 2018.

DOI:10.1155/2018/5134309
PMID:29808095
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5902081/
Abstract

Aortic atheromas (aortic atheromatous plaques) are defined by an irregular thickening of the intima ≥2 mm, and a complex plaque is defined as a protruding atheroma ≥4 mm with or without an attached mobile component. Stroke incidence is approximately 25% in patients with mobile plaques of the aortic arch and 2% in patients with quiescent nonmobile plaques. Antiplatelet agents, oral anticoagulants, and statins have been suggested in the management of atheromas. We present an 80-year-old male, with non-ST-segment elevation myocardial infarction (NSTEMI) and chronic dysarthria, found to have an acute cerebrovascular accident (CVA) secondary to embolism from a large 12 mm aortic arch plaque, treated medically with oral antiplatelet therapy, anticoagulation, and statin therapy.

摘要

主动脉粥样瘤(主动脉粥样斑块)定义为内膜不规则增厚≥2毫米,复杂斑块定义为突出的粥样瘤≥4毫米,伴有或不伴有附着的可移动成分。主动脉弓有可移动斑块的患者中风发生率约为25%,静止不可移动斑块的患者中风发生率为2%。抗血小板药物、口服抗凝剂和他汀类药物已被建议用于粥样瘤的治疗。我们报告一名80岁男性,患有非ST段抬高型心肌梗死(NSTEMI)和慢性构音障碍,发现因一枚12毫米的大型主动脉弓斑块栓塞继发急性脑血管意外(CVA),接受了口服抗血小板治疗、抗凝治疗和他汀类药物治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed01/5902081/b6b03756a715/CRIM2018-5134309.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed01/5902081/7e7b5e85ba4e/CRIM2018-5134309.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed01/5902081/5fdac599fc29/CRIM2018-5134309.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed01/5902081/705d5d4c7db0/CRIM2018-5134309.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed01/5902081/b6b03756a715/CRIM2018-5134309.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed01/5902081/7e7b5e85ba4e/CRIM2018-5134309.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed01/5902081/5fdac599fc29/CRIM2018-5134309.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed01/5902081/705d5d4c7db0/CRIM2018-5134309.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed01/5902081/b6b03756a715/CRIM2018-5134309.004.jpg

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Pro-inflammatory effect of fibrinogen on vascular smooth muscle cells by regulating the expression of α, γ and .纤维蛋白原通过调节α、γ和(此处原文不完整)的表达对血管平滑肌细胞产生促炎作用。
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Thoracic aortic mobile thrombus: is there a role for early surgical intervention?胸主动脉活动性血栓:早期手术干预是否有作用?
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Aortic arch plaques and risk of recurrent stroke and death.主动脉弓斑块与复发性中风及死亡风险
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