Costa Rubens Barros, Benson Al, Yaghmai Vahid, Costa Ricardo L B, Zhou Haijun, Behdad Amir, Kaplan Jason B, Sadim Maureen, Talamantes Sarah, Kalyan Aparna
Developmental Therapeutics Program, Feinberg School of Medicine and Robert H. Lurie Comprehensive Cancer Center of Northwestern University, 233 East Superior Street, Chicago, IL 60611, USA.
Division of Hematology and Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, 676 North Clair Street, Chicago, IL 60611, USA.
Case Rep Oncol Med. 2018 Apr 1;2018:6314392. doi: 10.1155/2018/6314392. eCollection 2018.
Pancreatic cancer is the fourth most common cancer death in the United States despite comprising a small percentage of the total number of cancer cases. The estimated 5-year overall survival (OS) for patients with distant metastatic disease is approximately 3%. New treatment options are an unmet need and remain an area of active investigation. A 53-year-old male with metastatic pancreatic cancer presented to the hospital with acute-on-chronic respiratory failure approximately 24 hours after receiving a novel therapeutic combination. Chest imaging showed marked changes as concerning for pneumonitis. Infectious workup was negative. The patient had initial clinical improvement after receiving initial intravenous steroids and oxygen support but eventually deteriorated later opting for supportive measures only. With infection ruled out, drug-induced pneumonitis was felt to be the likely cause of the radiologic and clinical changes. The rapidity of onset of symptoms is the aspect being highlighted in this case.
尽管胰腺癌在美国癌症病例总数中占比很小，但却是第四大常见的癌症死因。远处转移性疾病患者的估计5年总生存率约为3%。新的治疗选择尚未满足需求，仍是一个积极研究的领域。一名53岁的转移性胰腺癌男性患者在接受一种新型治疗组合后约24小时因急性加重的慢性呼吸衰竭入院。胸部影像学显示有明显变化，疑似肺炎。感染相关检查结果为阴性。患者在接受初始静脉注射类固醇和氧气支持后最初有临床改善，但最终病情恶化，后来仅选择支持性措施。排除感染后，药物性肺炎被认为是影像学和临床变化的可能原因。本病例突出了症状出现的快速性。
