Elangovan Cheran, Morawo Adeolu, Ahmed Aiesha
Department of Neurology, Penn State University, 30 Hope Drive, EC 037, Hershey, PA, 17033, USA.
Curr Treat Options Neurol. 2018 May 28;20(7):23. doi: 10.1007/s11940-018-0510-9.
Peripheral nerve hyperexcitability (PNH) syndromes are divided into primary and secondary groups based on the presence or absence of demonstrable peripheral nerve disease. In this review, we systematically evaluate the evidence for current therapies and supportive managements based on autoimmune, paraneoplastic, and genetic components in pathophysiology reported in the literature.
Current therapy options are based on symptomatic management as well as focusing the underlying immune/genetic/paraneoplastic pathology by immunosuppressants, chemotherapy, and surgery. Further research is desired to provide treatment options geared specifically towards addressing PNH. Supportive care can also be an area for future research.
根据是否存在可证实的周围神经疾病，周围神经兴奋性增高（PNH）综合征分为原发性和继发性两类。在本综述中，我们基于文献报道的病理生理学中的自身免疫、副肿瘤和遗传成分，系统评估当前治疗方法和支持性管理的证据。
目前的治疗选择基于症状管理，以及通过免疫抑制剂、化疗和手术针对潜在的免疫/遗传/副肿瘤病理。需要进一步研究以提供专门针对PNH的治疗选择。支持性护理也可能是未来研究的一个领域。
