双层活细胞构建体与脱细胞胎牛胶原敷料治疗静脉性下肢溃疡的疗效比较。
Comparative effectiveness of a bilayered living cellular construct and an acellular fetal bovine collagen dressing in the treatment of venous leg ulcers.
机构信息
Managing Member Wound Care, Sabolinski LLC, 55 Jefferson Road, Franklin, MA 02038, USA.
Center for Wound Healing, South Shore Hospital, Suite 100, 90 Libbey Parkway, South Weymouth, MA 02189, USA.
出版信息
J Comp Eff Res. 2018 Aug;7(8):797-805. doi: 10.2217/cer-2018-0031. Epub 2018 May 29.
To compare the effectiveness of bilayered living cellular construct (BLCC) and an acellular fetal bovine collagen dressing (FBCD) for the treatment of venous leg ulcers. Data from WoundExpert (Net Health, PA, USA) was used to analyze 1021 refractory venous leg ulcers treated at 177 facilities. Kaplan-Meier analyses showed that BLCC (893 wounds) was superior to FBCD (128 wounds), p = 0.01 for: wound closure by weeks 12 (31 vs 25%), 24 (55 vs 43%) and 36 (68 vs 53%); reduction in time to wound closure of 37%, (19 vs 30 weeks); and improvement in the probability of healing by 45%. BLC versus FBCD showed significant differences in both time to and frequency of healing suggesting that BLCC may provide significant cost savings compared with FBCD.
比较双层活细胞构建体（BLCC）和脱细胞胎牛胶原蛋白敷料（FBCD）治疗静脉性腿部溃疡的效果。使用来自 WoundExpert（美国宾夕法尼亚州 Net Health）的数据，分析了在 177 个机构治疗的 1021 例难治性静脉性腿部溃疡。Kaplan-Meier 分析表明，BLCC（893 例伤口）优于 FBCD（128 例伤口），p=0.01，分别为：第 12 周（31%对 25%）、第 24 周（55%对 43%）和第 36 周（68%对 53%）的伤口闭合；伤口闭合时间减少 37%（19 周对 30 周）；愈合概率提高 45%。BLCC 与 FBCD 在愈合时间和频率方面均存在显著差异，表明与 FBCD 相比，BLCC 可能会带来显著的成本节约。
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