Assadiasl Sara, Mousavi Mohammad Javad, Amirzargar Aliakbar
>From the Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Exp Clin Transplant. 2018 Jun;16(3):245-252.
Toll-like receptor 4 is a member of the cell surface pattern recognition receptors involved in pathogenesis of several infectious and autoimmune diseases. The wide range of Toll-like receptor 4 extrinsic and intrinsic ligands means that it has considerable ability to trigger infectious and sterile inflammation, the latter assumed to be the principal cause of ischemia-reperfusion injury. With the rising number of renal transplant procedures using deceased donors, in addition to prolonged ischemia time due to organ transport and consequently increased risk of ischemia-induced injuries, the prevention of detrimental immune responses and/or overcoming these after they initiate could be beneficial for graft survival. This review aims to summarize past and present studies conducted about the role of Toll-like receptor 4 in early and late phases of transplant, including gene expression and polymorphism evaluations.
Toll样受体4是细胞表面模式识别受体家族的成员，参与多种感染性和自身免疫性疾病的发病机制。Toll样受体4的外源性和内源性配体种类繁多，这意味着它具有相当强的引发感染性和无菌性炎症的能力，后者被认为是缺血再灌注损伤的主要原因。随着使用已故供体的肾移植手术数量的增加，除了由于器官运输导致的缺血时间延长以及由此增加的缺血性损伤风险外，预防有害的免疫反应和/或在其引发后克服这些反应可能有利于移植物存活。本综述旨在总结过去和现在关于Toll样受体4在移植早期和晚期作用的研究，包括基因表达和多态性评估。
