Parlewar Rupali, Shaikh Rubiya
Indian J Physiol Pharmacol. 2016 Apr;60(2):128-136.
The present study is carried out to assess brainstem auditory evoked potentials in patients of COPD and to evaluate effects of COPD on it before any clinical signs and symptoms of auditory impairment appear. This early diagnosis will help in maintaining a better quality of life in patients of COPD. Study includes 100 individuals divided in two groups, study group (n=50) and controls (n=50). Study group consist of COPD patients those had duration of COPD for more than 5 years with stable course of disease. Latency of wave 1, 111, IV, Vwere prolonged in cases compared to controls in right ear and left ear. The difference is statistically significant (p value <0.05). Right ear interpeak latencies of 1-111, Ill-V and I-V were increased with statistical significance among cases compared to controls (p value <0.05). In left ear, interpeak latencies of I-l1l and I-V were statistically more (p value <0.05) in case group compared to control group. The subclinical BAEP impairment in patients of COPD was due to the severity of airflow obstruction which causes chronic hypoxemia. The progressive chronic hypoxemia leads to development of tissue hypoxia and decreases the cerebral Derfusion; also it slows the nerve conduction in auditory pathway which causes prolongation of latency.
本研究旨在评估慢性阻塞性肺疾病(COPD)患者的脑干听觉诱发电位,并在出现任何听觉损害的临床体征和症状之前,评估COPD对其的影响。这种早期诊断将有助于维持COPD患者更好的生活质量。研究包括100名个体,分为两组,研究组(n = 50)和对照组(n = 50)。研究组由COPD病程超过5年且病情稳定的COPD患者组成。与对照组相比,病例组右耳和左耳的波I、III、IV、V潜伏期延长。差异具有统计学意义(p值<0.05)。与对照组相比,病例组右耳I-III、III-V和I-V的峰间潜伏期增加,具有统计学意义(p值<0.05)。在左耳,病例组I-III和I-V的峰间潜伏期与对照组相比在统计学上更高(p值<0.05)。COPD患者的亚临床脑干听觉诱发电位损害是由于气流阻塞的严重程度导致慢性低氧血症。进行性慢性低氧血症导致组织缺氧的发展并减少脑灌注;它还会减慢听觉通路中的神经传导,从而导致潜伏期延长。