Narra Lakshmi Kamala, Ghate Jayshri, Sinha Meenakshi, Sinha Ramanjan
MBBS Final Year Student, AIIMS Raipur, India.
Associate Professor (Physiology), AIIMS Raipur, India.
Med J Armed Forces India. 2023 Mar-Apr;79(2):136-140. doi: 10.1016/j.mjafi.2020.08.017. Epub 2020 Dec 3.
Obesity is a chronic condition, affecting central and peripheral nervous system. Studies on cranial nerve conduction in obesity are scarce and unclear; therefore, we planned this study. The aim of this study was to evaluate optic and auditory nerve conductions in obesity.
It was a case-control study, with inclusion of 40 young males (20 obese and 20 controls) in age group of 18-30 years. We recorded pattern reversal visual evoked potential (PRVEP) and brainstem auditory evoked potential (BAEP). The PRVEP P100 latency and BAEP absolute and interpeak latencies were analyzed.
In obese individuals, BAEP absolute latencies of wave V were significantly prolonged in both the ears and wave I in left ear. In addition, significant prolongation of interpeak latency III-V was observed in both the ears and I-V latency, in right ear among obese cases. A positive correlation was seen between body mass index and interpeak latency I-V. In PRVEP recordings, P100 latency did not show any significant difference in both the groups.
Therefore, we can conclude that obesity does not affect optic nerve conduction, but auditory nerve conduction is affected. BAEP I-V interpeak latency may be an indicator of subclinical auditory conduction defects in young obese males.
肥胖是一种慢性疾病，会影响中枢和外周神经系统。关于肥胖患者颅神经传导的研究稀少且不明确；因此，我们开展了本研究。本研究的目的是评估肥胖患者的视神经和听神经传导情况。
这是一项病例对照研究，纳入了40名年龄在18至30岁的年轻男性（20名肥胖者和20名对照者）。我们记录了图形翻转视觉诱发电位（PRVEP）和脑干听觉诱发电位（BAEP）。分析了PRVEP的P100潜伏期以及BAEP的绝对潜伏期和峰间潜伏期。
在肥胖个体中，双耳的BAEP波V绝对潜伏期均显著延长，左耳的波I绝对潜伏期也显著延长。此外，肥胖病例中双耳的峰间潜伏期III-V以及右耳的I-V潜伏期均显著延长。体重指数与峰间潜伏期I-V呈正相关。在PRVEP记录中，两组的P100潜伏期均未显示出任何显著差异。
因此，我们可以得出结论，肥胖不影响视神经传导，但会影响听神经传导。BAEP的I-V峰间潜伏期可能是年轻肥胖男性亚临床听觉传导缺陷的一个指标。
