Vlakhov N, Georgiev P, Angelov G, Zheliazkova T
Biull Eksp Biol Med. 1985 Jan;99(1):25-6.
The enzymic tests and radionuclide hepatography were used to study and compare liver function after rabbits were exposed to tetrachloromethane poisoning. The activity of serum enzymes of cholinesterase, alkaline phosphatase, aldolase and leucine aminopeptidase was determined. Hepatography was made with the use of 198Au-colloid with an activity 0.74 MBC. The enzymic tests were demonstrated to be more sensitive than radionuclide hepatography in detecting the earliest parenchymatous lesions in the liver. The data obtained correlate with the data of the pathohistological examinations, which demonstrated the presence of marked vacuole parenchymatous fatty dystrophy. The authors recommend that the enzymic tests should be used for detecting early hepatic lesions induced by tetrachloromethane.
采用酶学检测和放射性核素肝显像技术，对家兔四氯化碳中毒后的肝功能进行了研究和比较。测定了血清胆碱酯酶、碱性磷酸酶、醛缩酶和亮氨酸氨基肽酶的活性。使用活度为0.74兆贝克勒尔的198Au-胶体进行肝显像。结果表明，在检测肝脏最早的实质性病变方面，酶学检测比放射性核素肝显像更敏感。所获数据与病理组织学检查结果相关，病理组织学检查显示存在明显的空泡性实质性脂肪营养不良。作者建议将酶学检测用于检测四氯化碳引起的早期肝脏病变。
