Kiuchi T, Kawasaki Y, Hino I, Kojima K, Ohkawa M, Tamai T, Tanabe M
Department of Radiology, Kagawa Medical School.
Nihon Igaku Hoshasen Gakkai Zasshi. 1994 Sep 25;54(10):1018-29.
Technetium-99m-DTPA-galactosyl human serum albumin (99mTc-GSA) is a new ligand that binds specifically to asialoglycoprotein receptors in hepatocytes. We performed liver dynamic SPECT using 99mTc-GSA and 99mTc-Sn colloid in nine normal control rabbits and 17 chronically CCI4-damaged rabbits (total 29 examinations), and also performed liver function tests (ICGR15, Alb, etc). Using the obtained dynamic SPECT data, we analyzed the liver kinetics of 99mTc-Sn colloid using a one-compartment model (hepatic blood flow [K]) and 99mTc-GSA using a two-compartment model (hepatic blood flow and receptor binding [K1], catabolism [K2]). As the CCl4-treated period increased, K1 decreased most significantly. K1 showed the most significant statistical correlation with the results of liver function tests, ICGR15 (p < 0.0001), Alb, PT, HP, Bil and GPT. Further, only K1 showed a correlation with the hepatic fibrosis of the HAI score. From the present results, liver dynamic SPECT using 99mTc-GSA may be said to provide a novel method for the evaluation of hepatic functional reserve.
锝-99m-二乙三胺五乙酸-半乳糖基人血清白蛋白（99mTc-GSA）是一种能特异性结合肝细胞去唾液酸糖蛋白受体的新型配体。我们对9只正常对照兔和17只长期受四氯化碳损伤的兔（共进行29次检查）使用99mTc-GSA和99mTc-锡胶体进行了肝脏动态单光子发射计算机断层扫描（SPECT），并进行了肝功能检查（吲哚菁绿15分钟滞留率[ICGR15]、白蛋白等）。利用获得的动态SPECT数据，我们用单室模型（肝血流量[K]）分析了99mTc-锡胶体的肝脏动力学，并用双室模型（肝血流量和受体结合[K1]、分解代谢[K2]）分析了99mTc-GSA的肝脏动力学。随着四氯化碳处理时间的增加，K1下降最为显著。K1与肝功能检查结果ICGR15（p<0.0001）、白蛋白、凝血酶原时间、血氨、胆红素和谷丙转氨酶显示出最显著的统计学相关性。此外，只有K1与肝纤维化的HAI评分相关。从目前的结果来看，使用99mTc-GSA进行肝脏动态SPECT可被认为是一种评估肝功能储备的新方法。
