Giannini A J, Loiselle R H, Price W A, Giannini M C
J Clin Psychiatry. 1985 Feb;46(2):52-4.
Patients with phencyclidine psychosis were treated with two 50 mg injections of either chlorpromazine (N = 10) or meperidine (N = 10). The chlorpromazine-treated group responded more rapidly, but the meperidine-treated group had greater overall improvement. It is suggested that meperidine may have a role in the emergency treatment of phencyclidine psychosis. These findings may provide support for the hypothesis that dopaminergic psychosis is mediated by opioids.
用50毫克氯丙嗪（N = 10）或哌替啶（N = 10）对苯环己哌啶精神病患者进行两次注射治疗。氯丙嗪治疗组反应更快，但哌替啶治疗组总体改善更大。提示哌替啶可能在苯环己哌啶精神病的急诊治疗中发挥作用。这些发现可能为多巴胺能精神病由阿片类药物介导的假说提供支持。
