Giannini A J, Loiselle R H, DiMarzio L R, Giannini M C
Am J Psychiatry. 1987 Sep;144(9):1207-9. doi: 10.1176/ajp.144.9.1207.
The authors studied 40 white men with acute phencyclidine (PCP) intoxication. On a random basis, 10 were treated with ascorbic acid, 10 with placebo, 10 with haloperidol, and 10 with a combination of ascorbic acid and haloperidol. While haloperidol was significantly more effective than ascorbic acid, the combination was significantly more effective than either used alone. This combination may have a specific antipsychotic role in the emergency treatment of PCP psychosis.
