Altmann D M, Blyth W A
Clin Exp Immunol. 1985 Jan;59(1):17-22.
Investigations were conducted to determine the effect of cyclosporin A (CsA) on the delayed type hypersensitivity (DTH) and antibody response of mice to Herpes simplex virus (HSV). Given only at the time of priming, the drug had little effect on the subsequent DTH response in mice receiving a 'DTH immunogenic' inoculation regime. However, CsA restored normal responsiveness in groups receiving a 'DTH tolerogenic' regime implying the abrogation of T suppressor (Ts) cells. Ts cell induction was insensitive to cyclophosphamide. Antibody responses were not suppressed after giving CsA with either of these regimes and enhancement was shown in some groups. DTH was substantially reduced by CsA when the drug was given repeatedly between the time of priming and challenge, or when previously primed mice received the drug shortly before challenge.
开展了多项研究以确定环孢素A（CsA）对小鼠迟发型超敏反应（DTH）以及对单纯疱疹病毒（HSV）抗体反应的影响。仅在初次免疫时给药，该药物对接受“DTH免疫原性”接种方案的小鼠随后的DTH反应影响很小。然而，CsA使接受“DTH耐受性”方案的组恢复了正常反应性，这意味着T抑制细胞（Ts）被消除。Ts细胞诱导对环磷酰胺不敏感。在这两种方案中任一种给药后给予CsA，抗体反应均未受到抑制，并且在一些组中显示有增强作用。当在初次免疫和激发之间反复给予该药物时，或者当先前已进行初次免疫的小鼠在激发前不久接受该药物时，CsA可使DTH大幅降低。
