Alward W L, McMahon B J, Hall D B, Heyward W L, Francis D P, Bender T R
J Infect Dis. 1985 Apr;151(4):604-9. doi: 10.1093/infdis/151.4.604.
One hundred fifty asymptomatic patients who were carriers of hepatitis B surface antigen (HBsAg) were studied serologically for up to 11.3 years (mean, 6.1 years). Only 9 (6.0%) lost HBsAg during the study period, for a mean annual clearance rate of 1.0%. We found no difference in the clearance of HBsAg by age, but a higher percentage of females lost HBsAg than did males (P less than .02). Hepatitis B e antigen (HBeAg) was found in 102 (68.5%) of the 149 carriers of HBsAg who were tested. Carriers of HBsAg who were seropositive for HBeAg were younger than those who were seronegative for HBeAg (P less than .01). The prevalence of HBeAg was not affected by the patients' sex. The clearance of HBeAg was gradual; 9.6% of the HBsAg carriers lost HBeAg each year. Females were more likely to clear HBeAg than were males (P less than .01), and those who cleared HBeAg were older than those who did not (P less than .01). Three (2.0%) of the HBsAg carriers developed primary hepatocellular carcinoma during the study period.
对150名无症状的乙型肝炎表面抗原（HBsAg）携带者进行了长达11.3年（平均6.1年）的血清学研究。在研究期间，只有9人（6.0%）的HBsAg转阴，平均年清除率为1.0%。我们发现，按年龄分组，HBsAg的清除率没有差异，但女性HBsAg转阴的比例高于男性（P<0.02）。在接受检测的149名HBsAg携带者中，有102人（68.5%）检测出乙型肝炎e抗原（HBeAg）。HBeAg血清学阳性的HBsAg携带者比HBeAg血清学阴性的携带者年轻（P<0.01）。HBeAg的流行率不受患者性别的影响。HBeAg的清除是逐渐发生的；每年有9.6%的HBsAg携带者HBeAg转阴。女性比男性更有可能清除HBeAg（P<0.01），清除HBeAg的人比未清除的人年龄更大（P<0.01）。在研究期间，有3名（2.0%）HBsAg携带者发生了原发性肝细胞癌。
