Viola L A, Barrison I G, Coleman J C, Paradinas F J, Murray-Lyon I M
J Med Virol. 1981;8(3):169-75. doi: 10.1002/jmv.1890080303.
HBeAg or anti HBe were detected using radioimmunoassay in 93 out of 100 British patients who were chronic HBsAg carriers. HBeAg was found more commonly than anti HBe in younger patients and those with higher titres of HbsAg and abnormal liver function tests. HBeAg was present particularly in patients with chronic active hepatitis (26 out of 29) and chronic persistent hepatitis (16 out of 21). Anti HBe was found particularly in healthy carriers (19 out of 27), and patients with cirrhosis (4 out of 8) and hepatocellular carcinoma (7 out of 8). However, the system was of little help in predicting the liver biopsy appearances in the individual patient. During a mean follow-up period of 44 months, 6 of the 62 (9.7%) HBeAg positive carriers converted to anti HBe, a spontaneous seroconversion rate of 2.68% per year.
在100名慢性乙肝表面抗原携带者的英国患者中，有93名患者通过放射免疫分析法检测出e抗原或e抗体。在年轻患者以及乙肝表面抗原滴度较高且肝功能检查异常的患者中，e抗原比e抗体更常见。e抗原尤其存在于慢性活动性肝炎患者（29例中有26例）和慢性持续性肝炎患者（21例中有16例）中。e抗体尤其在健康携带者（27例中有19例）、肝硬化患者（8例中有4例）和肝细胞癌患者（8例中有7例）中被发现。然而，该系统在预测个体患者的肝活检表现方面帮助不大。在平均44个月的随访期内，62名e抗原阳性携带者中有6名（9.7%）转为e抗体阳性，自发血清学转换率为每年2.68%。
