Kotlarek F, Deselaers M, Hotes G
Klin Padiatr. 1985 Jan-Feb;197(1):21-4. doi: 10.1055/s-2008-1033920.
A fatal incident during combined anticonvulsive therapy with ACTH and Dexamethason prompted us to reevaluate our treatment results in 19 children suffering from infantile spasms. We followed Doose's recommendation using Clonazepam as a means of first choice. Failing that, than Dexamethason and Primidone was used. A combination of ACTH, Dexamethason and Primidone was administered to patients failing both treatment courses. Our results question the necessity, the tolerance limit and the efficacy of this treatment schedule. Therefore we propose a prospective multicentric study to reinvestigate the therapeutic guideliness for infantile spasms.
在联合使用促肾上腺皮质激素（ACTH）和地塞米松进行抗惊厥治疗期间发生的一起致命事件促使我们重新评估了19例婴儿痉挛症患儿的治疗结果。我们遵循多泽的建议，将氯硝西泮作为首选治疗手段。若效果不佳，则使用地塞米松和扑米酮。对于两个疗程治疗均失败的患者，给予ACTH、地塞米松和扑米酮联合治疗。我们的研究结果对这种治疗方案的必要性、耐受限度和疗效提出了质疑。因此，我们提议开展一项前瞻性多中心研究，以重新调查婴儿痉挛症的治疗指南。
