De Siate A
Minerva Stomatol. 1979 Jul-Sep;28(3):201-7.
Treatment of 70 patients with acute and chronic odontogenic processes for 5-35 days (mean 10.9 days) with a new cobetalactamine is reported. Rapid resolution was noted in nosological groups marked by the presence of acute infection. Particular interest is attached to the effect of the drug on chronicisting infections, such as apical granuloma, maxillary osteitis, and radicular cysts, since these forms displayed a high degree of vascular isolation, were often sustained by a mixed flora, and had been previously treated with other antibiotics. Follow-up four weeks after the conclusion of treatment showed a low incidence of recurrences that was in all events lower than in earlier experiments with chemical antibiotics. There were no instances of intolerance or allergy.
报告了用一种新型头孢他美酯对70例急慢性牙源性疾病患者进行5至35天(平均10.9天)治疗的情况。在以急性感染为特征的疾病分类组中观察到症状迅速缓解。该药物对慢性感染(如根尖肉芽肿、上颌骨炎和根囊肿)的作用尤其令人关注,因为这些病症表现出高度的血管隔离,常由混合菌群引起,且此前曾用其他抗生素治疗过。治疗结束四周后的随访显示复发率较低,在所有情况下均低于早期使用化学合成抗生素的实验。未出现不耐受或过敏情况。