Larsen P D, Bloomer L C, Bray P F
Neurology. 1985 Mar;35(3):435-8. doi: 10.1212/wnl.35.3.435.
To characterize the antibody response to the Epstein-Barr virus (EBV) in MS, we studied serum anti-EBV nuclear antigen (anti-EBNA) and anti-EBV capsid antigen (anti-EBVCA) titers. Both titers were assayed in 93 age- and sex-matched pairs of MS patients and controls. Anti-EBVCA titers were measured by indirect immunofluorescence and anti-EBNA titers by anticomplement immunofluorescence. The seropositivity rate of both anti-EBVCA and anti-EBNA in MS patients was 100%, compared with 84% in controls (p less than 0.0001). Both anti-EBVCA and anti-EBNA titers were significantly higher in MS patients than in controls (p less than 0.0001). The data suggest that EBV has a significant seroepidemiologic association with MS, but they do not define what role EBV antibodies play in the pathogenesis of the disease.
为了描述多发性硬化症（MS）患者对爱泼斯坦-巴尔病毒（EBV）的抗体反应，我们研究了血清抗EBV核抗原（抗EBNA）和抗EBV衣壳抗原（抗EBVCA）滴度。在93对年龄和性别匹配的MS患者及对照中检测了这两种滴度。抗EBVCA滴度通过间接免疫荧光法测定，抗EBNA滴度通过抗补体免疫荧光法测定。MS患者中抗EBVCA和抗EBNA的血清阳性率均为100%，而对照组为84%（p<0.0001）。MS患者的抗EBVCA和抗EBNA滴度均显著高于对照组（p<0.0001）。数据表明EBV与MS存在显著的血清流行病学关联，但并未明确EBV抗体在该疾病发病机制中所起的作用。
